Evidence map›Paper›PMID 30868057›Full record

ArticleFEBS open bio2019

RDM1 promotes neuroblastoma growth through the RAS-Raf-MEK-ERK pathway.

Guojin Xie, Haiyan Wu, Weiluo Cai, Mo Chen, Wending Huang, Wangjun Yan, Yong Chang

Open access · goldAbstract read
In one paragraph

Article in FEBS open bio, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Racially Disparate Expression of mTOR/ERK-1/2 Allied Proteins in Cancer.Frontiers in cell and developmental biology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Guojin XieChildren's Hospital of Nanjing Medical University Jiangsu China.
Haiyan WuChildren's Hospital of Nanjing Medical University Jiangsu China.
Weiluo CaiDepartment of Musculoskeletal Tumor Shanghai Cancer Center Fudan University Shanghai China.
Mo ChenDepartment of Musculoskeletal Tumor Shanghai Cancer Center Fudan University Shanghai China.
Wending HuangDepartment of Musculoskeletal Tumor Shanghai Cancer Center Fudan University Shanghai China.
Wangjun YanDepartment of Musculoskeletal Tumor Shanghai Cancer Center Fudan University Shanghai China.
Yong ChangChildren's Hospital of Nanjing Medical University Jiangsu China.
Fudan University Shanghai Cancer Center · CNSecond Affiliated Hospital of Nanjing Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neuroblastoma (NB) is an aggressive cancer that originates in the sympathetic nervous system and primarily affects children. Here, we show that high levels of RAD52 motif containing 1 (RDM1; a protein with similarities to RAD52, which is important for double-strand DNA repair) are associated with poor clinical outcomes for NB. In addition, RDM1

Indexed as

AnimalsApoptosisCell Cycle CheckpointsCell ProliferationDNA-Binding ProteinsFemaleHumansLung NeoplasmsMiceMice, Inbred BALB CMice, NudeMitogen-Activated Protein KinasesNeoplasms, ExperimentalNeuroblastomaProto-Oncogene Proteins p21(ras)raf KinasesDNA-Binding ProteinsMitogen-Activated Protein KinasesProto-Oncogene Proteins p21(ras)raf KinasesRDM1 protein, humanRNA, Small InterferingapoptosisneuroblastomaRAS–Raf–MEK–ERK pathwayRDM1

Identifiers

PMID30868057
PMCPMC6396142
OpenAlexW2906816588

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.