Evidence map›Paper›PMID 30867902›Full record

ArticleTranslational neurodegeneration2019

Blocking meningeal lymphatic drainage aggravates Parkinson's disease-like pathology in mice overexpressing mutated α-synuclein.

Wenyan Zou, Tinglin Pu, Weixi Feng, Ming Lu, Ying Zheng, Renhong Du, Ming Xiao, Gang Hu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational neurodegeneration, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 252 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
252citing papers in PubMed, 5 pooled it
13.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

252 citing papers in PubMed, 5 syntheses or guidelines pooled it, 363 citations in OpenAlex.

  1. Pooled it
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  5. Glymphatic System a Window on TBI Pathophysiology: A Systematic Review.International journal of molecular sciences · 2022
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  11. Shared genetic architecture between DTI-ALPS traits and neurodegenerative diseases.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
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  15. Article
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  17. The glymphatic system and Parkinson's disease: a narrative review.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Review
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  20. Article

192 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Wenyan Zou1Department of Pharmacology, School of Medicine and Life Sciences, Nanjing University of Chinese Medicine, 138 Xianlin Avenue, Nanjing, 210023 Jiangsu China.
Tinglin Pu2Jiangsu Key Laboratory of Neurodegeneratiion, Department of Pharmacology, Nanjing Medical University, 101 Longmian Avenue, Nanjing, 211166 Jiangsu China.
Weixi Feng2Jiangsu Key Laboratory of Neurodegeneratiion, Department of Pharmacology, Nanjing Medical University, 101 Longmian Avenue, Nanjing, 211166 Jiangsu China.
Ming Lu2Jiangsu Key Laboratory of Neurodegeneratiion, Department of Pharmacology, Nanjing Medical University, 101 Longmian Avenue, Nanjing, 211166 Jiangsu China.
Ying Zheng2Jiangsu Key Laboratory of Neurodegeneratiion, Department of Pharmacology, Nanjing Medical University, 101 Longmian Avenue, Nanjing, 211166 Jiangsu China.
Renhong Du2Jiangsu Key Laboratory of Neurodegeneratiion, Department of Pharmacology, Nanjing Medical University, 101 Longmian Avenue, Nanjing, 211166 Jiangsu China.
Ming Xiao2Jiangsu Key Laboratory of Neurodegeneratiion, Department of Pharmacology, Nanjing Medical University, 101 Longmian Avenue, Nanjing, 211166 Jiangsu China.ORCID 0000-0001-5528-9102
Gang Hu1Department of Pharmacology, School of Medicine and Life Sciences, Nanjing University of Chinese Medicine, 138 Xianlin Avenue, Nanjing, 210023 Jiangsu China.
Nanjing Medical University · CNNanjing University of Chinese Medicine · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAbnormal aggregation of brain α-synuclein is a central step in the pathogenesis of Parkinson's disease (PD), thus, it is reliable to promote the clearance of α-synuclein to prevent and treat PD. Recent studies have revealed an essential role of glymphatic system and meningeal lymphatic vessels in the clearance of brain macromolecules, however, their pathophysiological aspects remain elusive.

methodMeningeal lymphatic drainage of 18-week-old A53T mice was blocked via ligating the deep cervical lymph nodes. Six weeks later, glymphatic functions and PD-like phenotypes were systemically analyzed.

resultsGlymphatic influx of cerebrospinal fluid tracer was reduced in A53T mice, accompanied with perivascular aggregation of α-synuclein and impaired polarization of aquaporin 4 expression in substantia nigra. Cervical lymphatic ligation aggravated glymphatic dysfunction of A53T mice, causing more severe accumulation of α-synuclein, glial activation, inflammation, dopaminergic neuronal loss and motor deficits.

conclusionThe results suggest that brain lymphatic clearance dysfunction may be an aggravating factor in PD pathology.

Indexed as

A53T transgenic miceGlymphatic clearanceNeurodegenerationParkinson’s diseaseα-Synuclein

Identifiers

PMID30867902
PMCPMC6396507
OpenAlexW2924627473

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.