ArticleBiomicrofluidics2018
An artificial placenta type microfluidic blood oxygenator with double-sided gas transfer microchannels and its integration as a neonatal lung assist device.
Article in Biomicrofluidics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 49 citations in OpenAlex.
- Physiology-Mimicking Microfluidic Oxygenator with Good Hemocompatibility forMicromachines · 2026Article
- A silicon membrane microfluidic oxygenator for use as an artificial placenta with minimal anticoagulation.Bioengineering & translational medicine · 2025Article
- Oxygen transport in nanoporous SiN membrane compared to PDMS and polypropylene for microfluidic ECMO.Biomedical microdevices · 2025Article
- Oxygen Transport in Nanoporous SiN Membrane Compared to PDMS and Polypropylene for Microfluidic ECMO.bioRxiv : the preprint server for biology · 2025Article
- Roll-to-roll manufacturing of large surface area PDMS devices, and application to a microfluidic artificial lung.Lab on a chip · 2024Article
- Organ-on-a-chip: future of female reproductive pathophysiological models.Journal of nanobiotechnology · 2024Review
- Review
- An Insight on Microfluidic Organ-on-a-Chip Models for PMACS omega · 2024Review
- Toward 3D printed microfluidic artificial lungs for respiratory support.Lab on a chip · 2024Article
- A System for the Qualitative Testing of Microfluidic Artificial Lungs Using Water.International journal of engineering and technology : IJET · 2024Article
- Biomaterial strategies for the application of reproductive tissue engineering.Bioactive materials · 2022Review
- A Parametric Analysis of Capillary Height in Single-Layer, Small-Scale Microfluidic Artificial Lungs.Micromachines · 2022Article
- The path toward ectogenesis: looking beyond the technical challenges.BMC medical ethics · 2021Article
- Advances in extracorporeal membrane oxygenator design for artificial placenta technology.Artificial organs · 2021Review
- A Pumpless Microfluidic Neonatal Lung Assist Device for Support of Preterm Neonates in Respiratory Distress.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2020Article
- A biostable, anti-fouling zwitterionic polyurethane-urea based on PDMS for use in blood-contacting medical devices.Journal of materials chemistry. B · 2020Article
- Bioengineering models of female reproduction.Bio-design and manufacturing · 2020Article
- Assessing and improving the biocompatibility of microfluidic artificial lungs.Acta biomaterialia · 2020Article
- Engineered reproductive tissues.Nature biomedical engineering · 2020Review
- Organ-on-a-chip: recent breakthroughs and future prospects.Biomedical engineering online · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Preterm neonates suffering from respiratory distress syndrome require assistive support in the form of mechanical ventilation or extracorporeal membrane oxygenation, which may lead to long-term complications or even death. Here, we describe a high performance artificial placenta type microfluidic oxygenator, termed as a double-sided single oxygenator unit (dsSOU), which combines microwire stainless-steel mesh reinforced gas permeable membranes on both sides of a microchannel network, thereby significantly reducing the diffusional resistance to oxygen uptake as compared to the previous single-sided oxygenator designs. The new oxygenator is designed to be operated in a pumpless manner, perfused solely due to the arterio-venous pressure difference in a neonate and oxygenate blood through exposure directly to ambient atmosphere without any air or oxygen pumping. The best performing dsSOUs showed up to ∼343% improvement in oxygen transfer compared to a single-sided SOU (ssSOU) with the same height. Later, the dsSOUs were optimized and integrated to build a lung assist device (LAD) that could support the oxygenation needs for a 1-2 kg neonate under clinically relevant conditions for the artificial placenta, namely, flow rates ranging from 10 to 60 ml/min and a pressure drop of 10-60 mmHg. The LAD provided an oxygen uptake of 0.78-2.86 ml/min, which corresponded to the increase in oxygen saturation from 57 ± 1% to 93%-100%, under pure oxygen environment. This microfluidic lung assist device combines elegant design with new microfabrication methods to develop a pumpless, microfluidic blood oxygenator that is capable of supporting 30% of the oxygen needs of a pre-term neonate.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.