Evidence map›Paper›PMID 30867738›Full record

ArticleOncology letters2019

Addition of free poloxamer 407 to a new gene vector P407-PEI-K12 solution forms a sustained-release

Hongmei Shu, Yaguang Zhang, Min Zhang, Junwen Wu, Mingxiao Cui, Kehai Liu, Jun Wang

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncology letters, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Hongmei ShuDepartment of Biopharmaceutics, College of Food Science and Technology, Shanghai Ocean University, Shanghai 201306, P.R. China.
Yaguang ZhangDepartment of Biopharmaceutics, College of Food Science and Technology, Shanghai Ocean University, Shanghai 201306, P.R. China.
Min ZhangDepartment of Biopharmaceutics, College of Food Science and Technology, Shanghai Ocean University, Shanghai 201306, P.R. China.
Junwen WuDepartment of Biopharmaceutics, College of Food Science and Technology, Shanghai Ocean University, Shanghai 201306, P.R. China.
Mingxiao CuiDepartment of Biopharmaceutics, College of Food Science and Technology, Shanghai Ocean University, Shanghai 201306, P.R. China.
Kehai LiuDepartment of Biopharmaceutics, College of Food Science and Technology, Shanghai Ocean University, Shanghai 201306, P.R. China.
Jun WangDepartment of Gynaecology and Obstetrics, East Branch, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 201306, P.R. China.
Shanghai Ocean University · CNShanghai Sixth People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To address the concern around the efficiency/cytotoxicity ratio and the tumor-targeting effects of polyethylenimine (PEI), is a non-viral gene vector used for the delivery of the cancer therapy gene, poloxamer 407 (P407)-PEI-K12, was synthesized by cross-linking low-molecular weight PEI with P407 and further coupling a bifunctional peptide, K12, which is comprised of the tumor-targeting peptide tLyP-1 and the nuclear localization sequence. Furthermore, the addition of free P407 into the polymer/DNA complex solution produced a temperature-sensitive

Indexed as

gelsnon-viral gene vectorP407/P407-PEI-K12poloxamer 407polyethyleniminesustained-releasetransfection efficiency

Identifiers

PMID30867738
PMCPMC6396215
OpenAlexW2909721639

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.