ArticleExperimental and therapeutic medicine2019
VEGF and sFLT-1 in serum of PIH patients and effects on the foetus.
Article in Experimental and therapeutic medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 26 citations in OpenAlex.
- Engineering human multi-organ tissue chip niches for drug absorption, distribution, metabolism, excretion and toxicity prediction.Nature biomedical engineering · 2026Review
- Insight to Neglected Biomarkers in COVID-19: A Comprehensive Narrative Review".Biomarker insights · 2026Review
- Navigating Cellular Stress: Endoplasmic Reticulum Stress and the Unfolded Protein Response in the Molecular Pathogenesis of Preeclampsia.Cell biochemistry and biophysics · 2025Review
- Non-invasive left ventricular myocardial work indices in preterm neonates born to mothers with severe preeclampsia in pregnancy.Archives of gynecology and obstetrics · 2025Article
- Risk factors for refractory respiratory distress syndrome among very-low-birth-weight infants.BMC pediatrics · 2024Article
- Maternal angiogenic factor disruptions prior to clinical diagnosis of preeclampsia: insights from the REVAMP study.Hypertension research : official journal of the Japanese Society of Hypertension · 2024Article
- IL-6 Polymorphism as a Predisposing Genetic Factor for Gestational Diabetes or Preeclampsia Development in Pregnancy with Obesity in Relation to VEGF and VEGFF Receptor Gene Expression Modalities.Diagnostics (Basel, Switzerland) · 2024Article
- Article
- Machine learning-based protein signatures for differentiating hypertensive disorders of pregnancy.Hypertension research : official journal of the Japanese Society of Hypertension · 2023Article
- Metabolomic analysis-identified 2-hydroxybutyric acid might be a key metabolite of severe preeclampsia.Open life sciences · 2023Article
- Assessment of myocardial injury in neonates born to pregnant women with pregnancy complicated by severe preeclampsia by myocardial work indices: a prospective study.Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2022Article
- Effect of Placenta-Derived Mesenchymal Stromal Cells Conditioned Media on an LPS-Induced Mouse Model of Preeclampsia.International journal of molecular sciences · 2022Article
- The Impact of Increased Maternal sFlt-1/PlGF Ratio on Motor Outcome of Preterm Infants.Frontiers in endocrinology · 2022Article
- HIF-1α regulated pathomechanism of low birth weight through angiogenesis factors in placentalF1000Research · 2022Article
- Clinical value of serum VEGF and sFlt-1 in pernicious placenta previa.Annals of medicine · 2021Article
- Maternal vascular endothelial growth factor receptor and interleukin levels in pregnant women with twin-twin transfusion syndrome.International journal of medical sciences · 2021Observational
- Oxygen therapy in preterm infants with pulmonary hypertension.Seminars in fetal & neonatal medicine · 2020Review
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The expression of vascular endothelial growth factor (VEGF) and soluble fms-like tyrosine kinase-1 (sFLT-1) in the serum of patients with pregnancy induced hypertension (PIH) syndrome and its effects on the foetus was explored. A total of 105 cases of PIH pregnant women admitted to The First People's Hospital of Changzhou from March 2015 to February 2018 were divided into 3 groups according to the severity of the patients condition. Group A (n=35) was hypertension complicating pregnancy, group B (n=46) was mild preeclampsia and group C (n=24) was severe preeclampsia. In addition, 35 healthy pregnant women were selected as the control group. VEGF and sFLT-1 levels in serum were detected by enzyme linked immunosorbent assay, and the correlations between levels of VEGF and sFLT-1, neonatal weight and Apgar score were analyzed. Compared with group A, the level of serum VEGF was lower, while the level of sFLT-1 was higher in groups B and C (P<0.05). Compared with group B, the serum VEGF level in group C decreased significantly (P<0.05), while the serum level of sFLT-1 increased significantly (P<0.05). Compared with group A, neonatal weight and Apgar score in group C was significantly lower (P<0.05). There was a positive correlation between the serum VEGF level and neonatal weight and Apgar score (r=0.435, P<0.001. r=0.357, P<0.001). There was a negative correlation between the serum sFLT-1 level and neonatal weight and Apgar score (r=-0.351, P<0.001. r=-0.422, P<0.001). Therefore, we concluded that VEGF and sFlt-1 may be involved in the occurrence and development of PIH. The decrease of serum VEGF level and the increase of sFlt-1 level may be related to the inhibited fetal growth and development, which is of great significance in the clinical detection of PIH patients.
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