ArticleJournal of medical biochemistry2019
A Pilot Study to Assess Kidney Functions and Toxic Dimethyl-arginines as Risk Biomarkers in Women with Low Vitamin D Levels.
Article in Journal of medical biochemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 17 citations in OpenAlex.
- Discovery of novel PRMT1 inhibitors: a combined approach using AI classification model and traditional virtual screening.Frontiers in chemistry · 2025Article
- Lipid status association with 25-hydroxy vitamin D: Cross sectional study of end stage renal disease patients.Journal of medical biochemistry · 2020Article
- Dynamic thiol/disulfide homeostasis and oxidant status in patients with hypoparathyroidism.Journal of medical biochemistry · 2020Article
- Vitamin D and thiol-disulfide homeostasis levels in postmenopausal women with overactive bladder syndrome.Journal of medical biochemistry · 2020Article
- Assessment of Abbott Architect 25-OH vitamin D assay in different levels of vitamin D.Journal of medical biochemistry · 2020Article
- Anticoagulative activity ofInternational journal of health sciencesArticle
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlthough vitamin D in not a traditional marker for cardiovascular and renal diseases, several studies have proposed a correlation between vitamin D deficiency and these diseases due to the effect of vitamin D on endothelial function. Asymmetric and symmetric dimethyl arginine (ADMA and SDMA, respectively) are endogenous markers of endothelial dysfunction, and are considered as future markers for the assessment of cardiovascular and renal diseases. The present study investigated the association of kidney function tests (urea and creatinine) and dimethylarginine toxins (ADMA and SDMA) in women with vitamin D insufficiency or deficiency. Indeed, sex hormones (estrogen and testosterone) were analyzed in the participants.
methodsWomen were divided into two groups: premenopausal women (younger than 50 years) and postmenopausal women (older than 50 years). Urea, creatinine, estrogen, testosterone, ADMA, and SDMA levels were analyzed when vitamin D level was deficient or insufficient in the participants.
resultsThe premenopausal women group showed no significant correlations between dimethylarginine toxins and renal failure tests or sex hormones. In the elderly (postmenstrual) women group, only SDMA was significantly correlated with urea and creatinine, while both ADMA and SDMA were not correlated with sex hormones.
conclusionsAlthough ADMA and SDMA are promising candidates of endothelial dysfunction and are increased in menopause and aging, no direct link between ADMA and further progression of renal failure was observed in women with low vitamin D levels. In contrast, a possible direct correlation between SDMA and renal dysfunction was noticed, but only in an age-dependent manner.
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