ArticleNature2019
Small-molecule ion channels increase host defences in cystic fibrosis airway epithelia.
Abstract read
In one paragraph
Article in Nature, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed
12.0field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
48 citing papers in PubMed, 106 citations in OpenAlex.
- Topological Doping of Charged Bottlebrush Polymers for Efficient Artificial Ion Channels.Polymer science & technology (Washington, D.C.) · 2026Article
- Combining Gene Therapy with Current Modulator Treatments for Cystic Fibrosis: A Promising Area of Research.Pharmaceutics · 2026Review
- Artificial Transmembrane Channels for Selective Ascorbic Acid Transport and Bioorthogonal Signal Transduction.Angewandte Chemie (International ed. in English) · 2026Article
- Amino acid appended supramolecular self-associating amphiphiles demonstrate dual activity against both MRSA and ovarian cancer.Chemical science · 2026Article
- Targeting the polyene chain represents an adjuvant strategy for optimizing polyene antifungals.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Bioactive Sphingosine from Ficus racemosa: Isolation, Structural Elucidation, DFT Studies and Cytotoxic Potential against Oral Carcinoma Cells Via in Vitro and in Silico Approaches.Applied biochemistry and biotechnology · 2026Article
- Molecular Prosthetics and CFTR Modulators Additively Increase Secretory HCOACS chemical biology · 2025Article
- Article
- Medical and Nonmedical Applications of Synthetic Transmembrane Anion Transporters.Chemical reviews · 2025Review
- Supramolecular macrocyclic artificial ion channels for biomedical applications.Fundamental research · 2025Review
- Molecular prosthetics for CFTR designed for anion selectivity outperform amphotericin B in cultured cystic fibrosis airway epithelia.bioRxiv : the preprint server for biology · 2025Article
- Minimizing higher-order aggregation maximizes iron mobilization by small molecules.Nature chemical biology · 2024Article
- CFTR dysfunction leads to defective bacterial eradication on cystic fibrosis airways.Frontiers in physiology · 2024Review
- Aromatic pentaamide macrocycles bind anions with high affinity for transport across biomembranes.Nature chemistry · 2023Article
- Transmembrane Transport of Bicarbonate by Anion Receptors.ChemPlusChem · 2022Review
- A Nod and a WNK (Kinase): Understanding Airway Surface Liquid pH.American journal of respiratory cell and molecular biology · 2022Article
- WNK Inhibition Increases Surface Liquid pH and Host Defense in Cystic Fibrosis Airway Epithelia.American journal of respiratory cell and molecular biology · 2022Article
- Measuring anion binding at biomembrane interfaces.Nature communications · 2022Article
- IL-13-programmed airway tuft cells produce PGE2, which promotes CFTR-dependent mucociliary function.JCI insight · 2022Article
- Ion Channels and Transporters as Therapeutic Agents: From Biomolecules to Supramolecular Medicinal Chemistry.Biomedicines · 2022Review
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 1 country.
Katrina A MuragliaDepartment of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
Rajeev S ChorghadeDepartment of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
Bo Ram KimDepartment of Internal Medicine and HHMI, Pappajohn Biomedical Institute, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA, USA.
Xiao Xiao TangDepartment of Internal Medicine and HHMI, Pappajohn Biomedical Institute, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA, USA.
Viral S ShahDepartment of Internal Medicine and HHMI, Pappajohn Biomedical Institute, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA, USA.
Anthony S GrilloDepartment of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
Page N DanielsDepartment of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
Alexander G CioffiDepartment of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
Philip H KarpDepartment of Internal Medicine and HHMI, Pappajohn Biomedical Institute, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA, USA.
Lingyang ZhuDepartment of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
Michael J WelshDepartment of Internal Medicine and HHMI, Pappajohn Biomedical Institute, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA, USA.
Martin D BurkeDepartment of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, IL, USA. mdburke@illinois.edu.
University of Illinois Urbana-Champaign · USUniversity of Iowa · US
Funding
Respiratory virus infection in early cystic fibrosis lung diseaseP01HL091842 · NHLBI · UNIVERSITY OF IOWA · PI ZABNER, JOSEPH · 2008 to 2022
$34.2MVector Core-Core 2P30DK054759 · NIDDK · UNIVERSITY OF IOWA · PI Amy Leanne Ryan · 1998 to 2026
$30.5MMEDICAL SCIENTIST TRAINING PROGRAMT32GM007337 · NIGMS · UNIVERSITY OF IOWA · PI GEYER, PAMELA K., LENTZ, STEVEN R · 1985 to 2020
$15.9MMolecular Prosthetics and Lego ChemistryR35GM118185 · NIGMS · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI Martin D Burke · 2016 to 2026
$6.6MNHLBI NIH HHS P01 HL091842NIDDK NIH HHS P30 DK054759NIGMS NIH HHS R35 GM118185NIGMS NIH HHS T32 GM007337
Abstract
Loss-of-function mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) compromise epithelial HCO
Indexed as
Amphotericin BAnimalsBicarbonatesCells, CulturedCystic FibrosisCystic Fibrosis Transmembrane Conductance RegulatorEpithelial CellsEpitheliumFemaleHumansHydrogen-Ion ConcentrationIon ChannelsMaleRespiratory MucosaRespiratory SystemSodium-Potassium-Exchanging ATPaseAmphotericin BBicarbonatesCystic Fibrosis Transmembrane Conductance RegulatorIon ChannelsSodium-Potassium-Exchanging ATPase
Identifiers
What OpenQuestion holds
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.