Evidence map›Paper›PMID 30867597›Full record

ArticleNature2019

Glucocorticoids promote breast cancer metastasis.

Milan M S Obradović, Baptiste Hamelin, Nenad Manevski, Joana Pinto Couto, Atul Sethi, Marie-May Coissieux, Simone Münst, Ryoko Okamoto, Hubertus Kohler, Alexander Schmidt and 1 more

Registry-linked trialOpen access · greenAbstract read
PubMed Publisher
In one paragraph

Article in Nature, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04669132 (Efficacy of Olanzapine, Netupitant and Palonosetron in Controlling Nausea and Vomiting Associated With Highly Emetogenic Chemotherapy in Patients With Breast Cancer), which is not on this map. Cited by 269 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
269citing papers in PubMed, 3 pooled it
23.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04669132 phase2completednot on this mapstarted 2020, after this paper: background citation

Efficacy of Olanzapine, Netupitant and Palonosetron in Controlling Nausea and Vomiting Associated With Highly Emetogenic Chemotherapy in Patients With Breast Cancer

TypeinterventionalSponsorInstituto Brasileiro de Controle do CancerRan2020 to 2022Enrolled50ConditionsNausea Post ChemotherapyArmsOlanzapine, Netupitant, Palonesetron
3 · Its place in the literature

Who cites it

269 citing papers in PubMed, 3 syntheses or guidelines pooled it, 458 citations in OpenAlex.

  1. Pooled it
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  4. Neutrophils in cancer.Nature reviews. Cancer · 2026
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209 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 2 countries.

Milan M S ObradovićDepartment of Biomedicine, Department of Surgery, University Hospital Basel, University of Basel, Basel, Switzerland.
Baptiste HamelinDepartment of Biomedicine, Department of Surgery, University Hospital Basel, University of Basel, Basel, Switzerland.
Nenad ManevskiDivision of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland.
Joana Pinto CoutoDepartment of Biomedicine, Department of Surgery, University Hospital Basel, University of Basel, Basel, Switzerland.
Atul SethiDepartment of Biomedicine, Department of Surgery, University Hospital Basel, University of Basel, Basel, Switzerland.
Marie-May CoissieuxDepartment of Biomedicine, Department of Surgery, University Hospital Basel, University of Basel, Basel, Switzerland.
Simone MünstInstitute of Pathology, University Hospital Basel, University of Basel, Basel, Switzerland.
Ryoko OkamotoDepartment of Biomedicine, Department of Surgery, University Hospital Basel, University of Basel, Basel, Switzerland.
Hubertus KohlerFriedrich Miescher Institute for Biomedical Research, Basel, Switzerland.
Alexander SchmidtProteomics Core Facility, Biozentrum, University of Basel, Basel, Switzerland.
Mohamed Bentires-AljDepartment of Biomedicine, Department of Surgery, University Hospital Basel, University of Basel, Basel, Switzerland. m.bentires-alj@unibas.ch.
University of Basel · CHUniversity Hospital of Basel · CHFriedrich Miescher Institute · CHNovartis Institutes for BioMedical ResearchUniversity of Helsinki · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diversity within or between tumours and metastases (known as intra-patient tumour heterogeneity) that develops during disease progression is a serious hurdle for therapy

Indexed as

AnimalsBreast NeoplasmsCell Line, TumorDexamethasoneDisease ProgressionFemaleGlucocorticoidsHumansLung NeoplasmsMiceMice, Inbred BALB CNeoplasm MetastasisProtein KinasesReceptors, GlucocorticoidReceptor Tyrosine Kinase-like Orphan ReceptorsSignal TransductionDexamethasoneGlucocorticoidsProtein KinasesReceptors, GlucocorticoidReceptor Tyrosine Kinase-like Orphan ReceptorsROR1 protein, human

Identifiers

PMID30867597
OpenAlexW2920825919

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.