ArticleNature2019
Histone serotonylation is a permissive modification that enhances TFIID binding to H3K4me3.
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Article in Nature, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 290 papers.
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290citing papers in PubMed
18.6field-weighted citation impact, top 1% of its field
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Who cites it
290 citing papers in PubMed, 453 citations in OpenAlex.
- Epigenetic regulators polyphenols in neurodegenerative diseases: a promising intervention strategy.Annals of medicine · 2026Review
- Platelet-derived serotonin epigenetically programs macrophage alternative activation to orchestrate type 2 airway inflammation.Cellular & molecular immunology · 2026Article
- KMT2E recruitment by H3 serotonylation regulates neurodevelopmental chromatin dynamics.bioRxiv : the preprint server for biology · 2026Article
- Dynamic control of cell state transitions during tissue morphogenesis.The EMBO journal · 2026Review
- Cyclic stretch increases transglutaminase 2-mediated serotonylation of extracellular fibronectin in cultured optic nerve head astrocytes: a pilot study.Matrix biology plus · 2026Article
- Chemical Biology 2025: Highlights From the Ch/Bi145 Course at Caltech.Chembiochem : a European journal of chemical biology · 2026Review
- Altered Postnatal Chromatin Development in the Nucleus Accumbens Primes Enduring Stress Sensitivity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Chemical Proteomic Profiling of the Histaminylation Proteome in Cancer Cells Unveils Uncharted Epigenetic Marks on Core Histones.Journal of the American Chemical Society · 2026Article
- Mating-Induced Behavioral Changes in FemaleInternational journal of molecular sciences · 2026Article
- Post-translational modifications in metabolic reprogramming: implications for metabolic therapy and immunotherapy in cancer.Signal transduction and targeted therapy · 2026Review
- Article
- The impact of microbial metabolites on host chromatin and epigenetic regulation.Nature metabolism · 2026Review
- Linking cellular metabolism to chromatin modifications in plants.Journal of integrative plant biology · 2026Review
- Ythdf2/Setd1b regulatory axis is essential for cerebellar development through regulating epigenetic reprogramming.Molecular psychiatry · 2026Article
- Review
- Transglutaminase 2 Deletion Enhances Astrocyte-to-Neuron Metabolic Support and Attenuates Subacute Pathology Following Repetitive Mild Traumatic Brain Injury.bioRxiv : the preprint server for biology · 2026Article
- Crosstalk Between Gut Microbiota, Epigenome, and Neurotransmitters in Health and Disease.Cells · 2026Review
- Epigenetic Alterations in Hepatocellular Carcinoma: Mechanisms and Biomarkers for Precision Therapy.Cancers · 2026Review
- Epigenetic landscapes of classical psychedelics and ketamine: molecular mechanisms of long-lasting neuromodulation.Molecular psychiatry · 2026Review
- SLC22A3 regulates ferroptosis in the mesenchymal subtype of triple-negative breast cancer by modulating histone H3K4 serotonylation.Cell death & disease · 2026Article
230 more citing papers are in PubMed but not listed here.
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Authors and funding
27 authors at 9 institutions in 3 countries.
Lorna A FarrellyFishberg Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Robert E ThompsonDepartment of Chemistry, Princeton University, Princeton, NJ, USA.
Shuai ZhaoBeijing Advanced Innovation Center for Structural Biology, MOE Key Laboratory of Protein Sciences, Department of Basic Medical Sciences, School of Medicine, Tsinghua University, Beijing, China.
Ashley E LepackFishberg Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Yang LyuFishberg Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Natarajan V BhanuEpigenetics Institute, Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Baichao ZhangBeijing Advanced Innovation Center for Structural Biology, MOE Key Laboratory of Protein Sciences, Department of Basic Medical Sciences, School of Medicine, Tsinghua University, Beijing, China.
Yong-Hwee E LohFishberg Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Aarthi RamakrishnanFishberg Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Krishna C VadodariaLaboratory of Genetics, The Salk Institute for Biological Sciences, La Jolla, CA, USA.
Kelly J HeardLaboratory of Genetics, The Salk Institute for Biological Sciences, La Jolla, CA, USA.
Galina EriksonLaboratory of Genetics, The Salk Institute for Biological Sciences, La Jolla, CA, USA.
Tomoyoshi NakadaiLaboratory of Biochemistry and Molecular Biology, The Rockefeller University, New York, NY, USA.
Ryan M BastleFishberg Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Bradley J LukasakDepartment of Chemistry, Princeton University, Princeton, NJ, USA.
Henry ZebroskiThe Rockefeller University Proteomics Resource Center, The Rockefeller University, New York, NY, USA.
Natalia AleninaMax-Delbrück-Center for Molecular Medicine (MDC), Berlin, Germany.
Michael BaderMax-Delbrück-Center for Molecular Medicine (MDC), Berlin, Germany.
Olivier BertonFishberg Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Robert G RoederLaboratory of Biochemistry and Molecular Biology, The Rockefeller University, New York, NY, USA.
Henrik MolinaThe Rockefeller University Proteomics Resource Center, The Rockefeller University, New York, NY, USA.
Fred H GageLaboratory of Genetics, The Salk Institute for Biological Sciences, La Jolla, CA, USA.
Li ShenFishberg Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Benjamin A GarciaEpigenetics Institute, Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Haitao LiBeijing Advanced Innovation Center for Structural Biology, MOE Key Laboratory of Protein Sciences, Department of Basic Medical Sciences, School of Medicine, Tsinghua University, Beijing, China.
Tom W MuirDepartment of Chemistry, Princeton University, Princeton, NJ, USA.
Ian MazeFishberg Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. ian.maze@mssm.edu.
Allen Institute for Brain Science · USIcahn School of Medicine at Mount Sinai · USRockefeller University · USSalk Institute for Biological Studies · USPrinceton University · USMax Delbrück Center · DETsinghua University · CNUniversity of Pennsylvania · USCenter for Life Sciences · CN
Funding
REPRESSIVE HISTONE AND DNA METHYLATION IN RODENT DEPRESSION MODELSP50MH096890 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI ALLIS, CHARLES DAVID · 2012 to 2021
$20.2MShared Resources Core 2: Quantitative Proteomics CoreP01CA196539 · NCI · ROCKEFELLER UNIVERSITY · PI MUIR, TOM · 2015 to 2024
$17.6MStructure, Function and Applications of InteinsR37GM086868 · NIGMS · PRINCETON UNIVERSITY · PI MUIR, TOM · 2012 to 2021
$5.4MT32 Translational Addiction Research Fellowship ProgramT32DA028874 · NIDA · UNIVERSITY OF PENNSYLVANIA · PI Julie A Blendy, Anna Rose Childress · 2010 to 2026
$5.0MTRAINING IN PHARMACOLOGY OF DRUGS OF ABUSET32DA007135 · NIDA · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI DEVI, LAKSHMI A · 1985 to 2018
$4.9MMolecular studies of neural histone monoaminylation in normal and aberrant brain plasticityR01MH116900 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Ian S. Maze · 2019 to 2026
$4.7MMechanisms of p53 target gene activation in DNA damage responsesR01CA129325 · NCI · ROCKEFELLER UNIVERSITY · PI ROEDER, ROBERT G · 2007 to 2011
$4.0MFunctional and Mechanistic Study of Histone Crotonylation in Hematological MalignanciesR01CA204639 · NCI · ROCKEFELLER UNIVERSITY · PI ALLIS, CHARLES DAVID, ARMSTRONG, SCOTT A · 2016 to 2020
$3.5MRoles for histone monoaminylation in cocaine-induced transcriptional and behavioral plasticityDP1DA042078 · NIDA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI MAZE, IAN S. · 2016 to 2021
$3.2MUnderstanding the Role of Combinatorial Histone PTM PatternsR01GM110174 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI GARCIA, BENJAMIN A · 2014 to 2017
$1.3MApplication of intein-based chemical methods to directly manipulate neuronal histone modifications in rodent models of addictionR21DA044767 · NIDA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI DAVID-SHTERNBERG, YAEL E, MAZE, IAN S. · 2018 to 2019
$444kCocaine-induced histone post-translational modificationsR21DA040837 · NIDA · UNIVERSITY OF PENNSYLVANIA · PI GARCIA, BENJAMIN A, PIERCE, ROBERT CHRISTOPHER · 2016 to 2017
$440kNCI NIH HHS P01 CA196539NCI NIH HHS R01 CA129325NCI NIH HHS R01 CA204639NIDA NIH HHS DP1 DA042078NIDA NIH HHS R21 DA040837NIDA NIH HHS R21 DA044767NIDA NIH HHS T32 DA007135NIDA NIH HHS T32 DA028874NIGMS NIH HHS R01 GM110174NIGMS NIH HHS R37 GM086868NIMH NIH HHS P50 MH096890NIMH NIH HHS R01 MH116900
Abstract
Chemical modifications of histones can mediate diverse DNA-templated processes, including gene transcription
Indexed as
Gene Expression RegulationProtein Processing, Post-TranslationalAnimalsCell DifferentiationCell LineFemaleGlutamineGTP-Binding ProteinsHistonesHumansLysineMethylationMiceMice, Inbred C57BLProtein BindingProtein Glutamine gamma Glutamyltransferase 2GlutamineGTP-Binding Proteinshistone H3 trimethyl Lys4HistonesLysineProtein Glutamine gamma Glutamyltransferase 2SerotoninTGM2 protein, humanTranscription Factor TFIIDTransglutaminases
Identifiers
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.