Trial reportNature2019
Efficacy of MEK inhibition in patients with histiocytic neoplasms.
Registry-linked trialAbstract readClinical Trial
In one paragraph
Trial report in Nature, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06582745 (Targeted Approach to Langerhans Cell Histiocytosis), which is not on this map. Cited by 219 papers.
0numbers the graph read from it
0cells of the map it votes in
219citing papers in PubMed
23.0field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Targeted Approach to Langerhans Cell Histiocytosis (LCH) Using MEK Inhibitor, Trametinib
Who cites it
219 citing papers in PubMed, 371 citations in OpenAlex.
- Clofarabine for relapsed/refractory LCH and non-LC histiocytosis.Blood advances · 2026Trial
- Phase II Study of Ulixertinib in Children and Young Adults With Tumors Harboring Activating Mitogen-Activated Protein Kinase Pathway Alterations: APEC1621J of the National Cancer Institute-Children's Oncology Group Pediatric MATCH Trial.JCO precision oncology · 2024Trial
- Phase 2 study using low dose cytarabine for adult patients with newly diagnosed Langerhans cell histiocytosis.Leukemia · 2024Trial
- Phase II Study of Selumetinib in Children and Young Adults With Tumors Harboring Activating Mitogen-Activated Protein Kinase Pathway Genetic Alterations: Arm E of the NCI-COG Pediatric MATCH Trial.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2022Trial
- Efficacy and Tolerance of Cladribine for Non-Langerhans Cell Histiocytosis.European journal of haematology · 2026Article
- Article
- Dabrafenib plus trametinib in BRAF V600E-mutant Erdheim-Chester disease: a case series including CNS involvement.International journal of hematology · 2026Article
- Langerhans cell histiocytosis: molecular mechanisms underlying pathogenesis and emerging targeted therapeutics.Cancer metastasis reviews · 2026Review
- Local disease control in patients with Erdheim-Chester disease treated with external beam radiation therapy.British journal of haematology · 2026Article
- Histiocytosis development and clinical variation through the lens of genomics.The Journal of pathology · 2026Review
- Significant resolution of multiple adult-onset xanthogranulomas with MEK inhibitor therapy.JAAD case reports · 2026Article
- Outcome of treatment with trametinib in adults with histiocytic neoplasms in the United Kingdom.British journal of haematology · 2026Article
- ARAF mutated langerhans cell histiocytosis developed on the background of ARAF/JAK2 mutated polycythaemia vera: evidence of branching evolution from the same progenitor cell. A case report and literature review.Annals of hematology · 2026Review
- [A rare case of Rosai-Dorfman disease involving the pituitary stalk and presenting initially with diabetes insipidus].Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2026Article
- Cardiovascular Involvement in Erdheim-Chester Disease Presenting as Pericardial Tamponade: A Case Report and Multimodality Imaging Review.Journal of clinical medicine · 2026Review
- ERDHEIM-Chester Disease: Two Fatal Cases With Unusual Presentations.Clinical case reports · 2026Article
- Whole genome sequencing in oesophageal adenocarcinoma unmasks potential precision therapies.BMC cancer · 2026Article
- Unemployment in patients with histiocytic neoplasms is frequent and associated with clinical and treatment characteristics.Haematologica · 2026Article
- Targeted Therapy in Erdheim-Chester Disease: A Case Report and Review of the Literature.Cureus · 2026Article
- Article
159 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors at 3 institutions in 1 country.
Eli L DiamondDepartment of Neurology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Benjamin H DurhamDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Gary A UlanerWeill Cornell Medical College, New York, NY, USA.
Esther DrillDepartment of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Justin ButhornDepartment of Neurology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Michelle KiHuman Oncology and Pathogenesis Program, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Lillian BitnerHuman Oncology and Pathogenesis Program, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Hana ChoHuman Oncology and Pathogenesis Program, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Robert J YoungWeill Cornell Medical College, New York, NY, USA.
Jasmine H FrancisOphthalmic Oncology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Raajit RampalWeill Cornell Medical College, New York, NY, USA.
Mario LacoutureWeill Cornell Medical College, New York, NY, USA.
Lynn A BrodyDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Neval OzkayaDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Ahmet DoganDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Neal RosenWeill Cornell Medical College, New York, NY, USA.
Alexia IasonosWeill Cornell Medical College, New York, NY, USA.
Omar Abdel-WahabWeill Cornell Medical College, New York, NY, USA. abdelwao@mskcc.org.
David M HymanWeill Cornell Medical College, New York, NY, USA. hymand@mskcc.org.
Memorial Sloan Kettering Cancer Center · USCornell University · USNational Cancer Institute · US
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4MStudies on oncoprotein-induced feedback: Basic and therapeutic implicationsR35CA210085 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI ROSEN, NEAL · 2016 to 2022
$7.3MOrigins of BRAF-mutant hematologic malignancies and their therapeutic resistanceR01CA201247 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI ABDEL-WAHAB, OMAR, PARK, CHRISTOPHER Y · 2016 to 2020
$2.7MCellular Origins, Molecular Pathogenesis, and Novel Therapeutic Strategies for MAP Kinase-Driven Hematological MalignanciesK08CA218901 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI DURHAM, BENJAMIN HEATH · 2018 to 2022
$1.0MNCI NIH HHS K08 CA218901NCI NIH HHS L30 CA231804NCI NIH HHS P30 CA008748NCI NIH HHS R01 CA201247NCI NIH HHS R35 CA210085
Abstract
Histiocytic neoplasms are a heterogeneous group of clonal haematopoietic disorders that are marked by diverse mutations in the mitogen-activated protein kinase (MAPK) pathway
Indexed as
AzetidinesHistiocytic Disorders, MalignantHistiocytosisHumansMAP Kinase Kinase 1MAP Kinase Kinase 2MAP Kinase Signaling SystemMitogen-Activated Protein Kinase KinasesMutationPiperidinesProgression-Free SurvivalProto-Oncogene Proteins B-rafProto-Oncogene Proteins c-rafAzetidinesBRAF protein, humancobimetinibMAP2K1 protein, humanMAP2K2 protein, humanMAP Kinase Kinase 1MAP Kinase Kinase 2Mitogen-Activated Protein Kinase KinasesPiperidinesProto-Oncogene Proteins B-rafProto-Oncogene Proteins c-rafRaf1 protein, human
Identifiers
What OpenQuestion holds
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Read underepoch 390
Registered trials
NCT06582745ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.