ReviewMolecular psychiatry2019
Resilience as a translational endpoint in the treatment of PTSD.
Review in Molecular psychiatry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
37 citing papers in PubMed, 71 citations in OpenAlex.
- Social hierarchy and resilience affect stress-induced PTSD via Uba7 gene expression and subsequent inflammation in microglia of the mPFC.Molecular psychiatry · 2026Article
- Use of Single Prolonged Stress to Model Post-traumatic Stress Disorder in Rodents: What We Found and Where to Next?Current neuropharmacology · 2026Review
- Adult hippocampal neurogenesis-mediated cognitive behavior participates in stress resilience to anxiety and depression-like behaviors in postpartum dams.Molecular psychiatry · 2025Article
- Post-traumatic stress status among emergency department nurses during the winter H1N1 influenza season and correlations with burnout, coping, resilience, and support.Frontiers in psychology · 2025Article
- Predictors of posttraumatic stress disorder among displaced families in Lebanon: A cross-sectional study.PLOS global public health · 2025Article
- Resilience and its association with hopelessness, depression, loneliness, post-traumatic stress disorder (PTSD) and suicidal ideations and behavior in a cohort in the Nairobi Metropolitan.Global mental health (Cambridge, England) · 2025Article
- A cross-sectional network analysis of successful aging in a resilience-based framework.PloS one · 2025Article
- Fertility Stress, Psychological Resilience, and Depressive Symptoms in Women With Polycystic Ovary Syndrome.Cureus · 2024Article
- Resilience and Mental-Health Symptoms in ICU Healthcare Professionals Facing Repeated COVID-19 Waves.American journal of respiratory and critical care medicine · 2024Article
- Unconditioned response to a naturally aversive stimulus is associated with sensitized defensive responding and self-reported fearful traits in a PTSD sample.Psychophysiology · 2024Article
- The Effect of COVID-19 on Middle-Aged Adults' Mental Health: A Mixed-Method Case-Control Study on the Moderating Effect of Cognitive Reserve.Healthcare (Basel, Switzerland) · 2024Article
- Bedtime regularity predicts positive affect among veterans with posttraumatic stress disorder: an ecological momentary assessment study.BMC psychiatry · 2023Article
- Psychological Resilience in U.S. Military Veterans: Results from the 2019-2020 National Health and Resilience in Veterans Study.The Psychiatric quarterly · 2023Article
- Predicting Fear Extinction in Posttraumatic Stress Disorder.Brain sciences · 2023Article
- The Queensland Twin Adolescent Brain Project, a longitudinal study of adolescent brain development.Scientific data · 2023Article
- Posttraumatic Stress Symptom Trajectories in Family Caregivers of Patients With Acute Cardiorespiratory Failure.JAMA network open · 2023Article
- Posttraumatic stress symptom severity predicts cognitive decline beyond the effect of Alzheimer's disease biomarkers in Veterans.Translational psychiatry · 2023Article
- Burnout and post-traumatic stress disorder symptoms among medical staff two years after the COVID-19 pandemic in Wuhan, China: Social support and resilience as mediators.Journal of affective disorders · 2023Article
- The impact of resilience on the mental health of military personnel during the COVID-19 pandemic: coping styles and regulatory focus.Frontiers in public health · 2023Article
- Musical experience prior to traumatic exposure as a resilience factor: a conceptual analysis.Frontiers in psychology · 2023Review
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
Resilience is a neurobiological entity that shapes an individual's response to trauma. Resilience has been implicated as the principal mediator in the development of mental illness following exposure to trauma. Although animal models have traditionally defined resilience as molecular and behavioral changes in stress responsive circuits following trauma, this concept needs to be further clarified for both research and clinical use. Here, we analyze the construct of resilience from a translational perspective and review optimal measurement methods and models. We also seek to distinguish between resilience, stress vulnerability, and posttraumatic growth. We propose that resilience can be quantified as a multifactorial determinant of physiological parameters, epigenetic modulators, and neurobiological candidate markers. This multifactorial definition can determine PTSD risk before and after trauma exposure. From this perspective, we propose the use of an 'R Factor' analogous to Spearman's g factor for intelligence to denote these multifactorial determinants. In addition, we also propose a novel concept called 'resilience reserve', analogous to Stern's cognitive reserve, to summarize the sum total of physiological processes that protect and compensate for the effect of trauma. We propose the development and application of challenge tasks to measure 'resilience reserve' and guide the assessment and monitoring of 'R Factor' as a biomarker for PTSD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.