ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2019
Multimodal neurocognitive markers of interoceptive tuning in smoked cocaine.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.
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Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Heartbeat-Evoked Responses in M/EEG: A Systematic Review of Methods With Suggestions for Analysis and Reporting.Psychophysiology · 2026Pooled it
- Neural mechanisms of brand love relationship dynamics: Is the development of brand love relationships the same as that of interpersonal romantic love relationships?Frontiers in neuroscience · 2022Pooled it
- Altered processing of self-produced sensations in psychosis at cortical and spinal levels.Molecular psychiatry · 2025Article
- Neural Interoceptive Processing Is Modulated by Deep Brain Stimulation to Subcallosal Cingulate Cortex for Treatment-Resistant Depression.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2025Article
- Interoceptive Processing in Substance Use Disorders (SUDs): From the Neuroanatomy to Insights from Computational Models and Predictive Coding Frameworks.Current topics in behavioral neurosciences · 2025Review
- Exploring the Link Between Interoception and Symptom Severity in Premature Ventricular Contractions.Journal of clinical medicine · 2024Article
- Hub disruption in HIV disease and cocaine use: A connectomics analysis of brain function.Drug and alcohol dependence · 2024Article
- Neuroanatomical markers of social cognition in neglected adolescents.Neurobiology of stress · 2024Article
- Cocaine Use Prediction With Tensor-Based Machine Learning on Multimodal MRI Connectome Data.Neural computation · 2023Article
- Thinking versus feeling: How interoception and cognition influence emotion recognition in behavioural-variant frontotemporal dementia, Alzheimer's disease, and Parkinson's disease.Cortex; a journal devoted to the study of the nervous system and behavior · 2023Article
- Interoception Within the Context of Impulsivity and Addiction.Current addiction reports · 2023Review
- Ecological Meanings: A Consensus Paper on Individual Differences and Contextual Influences in Embodied Language.Journal of cognition · 2023Article
- Moral Emotions and Their Brain Structural Correlates Across Neurodegenerative Disorders.Journal of Alzheimer's disease : JAD · 2023Article
- Multidimensional inhibitory signatures of sentential negation in behavioral variant frontotemporal dementia.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Multimodal Neurocognitive Markers of Naturalistic Discourse Typify Diverse Neurodegenerative Diseases.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Heart-brain interactions during social and cognitive stress in hypertensive disease: A multidimensional approach.The European journal of neuroscience · 2022Article
- Mindfulness-Based Interventions for the Treatment of Aberrant Interoceptive Processing in Substance Use Disorders.Brain sciences · 2022Review
- Alcohol use and interoception - A narrative review.Progress in neuro-psychopharmacology & biological psychiatry · 2021Review
- Neuroanatomy of complex social emotion dysregulation in adolescent offenders.Cognitive, affective & behavioral neuroscience · 2021Article
- Interoception Primes Emotional Processing: Multimodal Evidence from Neurodegeneration.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
Corrections and comments
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Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Contemporary neurocognitive models of drug addiction have associated this condition with changes in interoception -namely, the sensing and processing of body signals that fulfill homeostatic functions relevant for the onset and maintenance of addictive behavior. However, most previous evidence is inconsistent, behaviorally unspecific, and virtually null in terms of direct electrophysiological and multimodal markers. To circumvent these limitations, we conducted the first assessment of the relation between cardiac interoception and smoked cocaine dependence (SCD) in a sample of (a) 25 participants who fulfilled criteria for dependence on such a drug, (b) 22 participants addicted to insufflated clorhidrate cocaine (only for behavioral assessment), and (c) 25 healthy controls matched by age, gender, education, and socioeconomic status. We use a validated heartbeat-detection (HBD) task and measured modulations of the heart-evoked potential (HEP) during interoceptive accuracy and interoceptive learning conditions. We complemented this behavioral and electrophysiological data with offline structural (MRI) and functional connectivity (fMRI) analysis of the main interoceptive hubs. HBD and HEP results convergently showed that SCD subjects presented ongoing psychophysiological measures of enhanced interoceptive accuracy. This pattern was associated with a structural and functional tuning of interoceptive networks (reduced volume and specialized network segregation). Taken together, our findings provide the first evidence of an association between cardiac interoception and smoked cocaine, partially supporting models that propose hyper-interoception as a key aspect of addiction. More generally, our study shows that multimodal assessments of interoception could substantially inform the clinical and neurocognitive characterization of psychophysiological and neurocognitive adaptations triggered by addiction.
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