ArticleScientific reports2019
Mesolimbic white matter connectivity mediates the preference for sweet food.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 11 citations in OpenAlex.
- Insulin sensitivity in mesolimbic pathways predicts and improves with weight loss in older dieters.eLife · 2022Trial
- Understanding Lifestyle Dissonance: A Neurobiological Narrative to Strengthen Preventive Health Behavior.European journal of neurology · 2026Review
- Differential exposure to palatable food and its effects on binge-like eating behavior in adolescent rats.Frontiers in psychology · 2024Article
- Hypothalamic microstructure and function are related to body mass, but not mental or cognitive abilities across the adult lifespan.GeroScience · 2023Article
- Alteration of neuroinflammation detected byEJNMMI research · 2021Article
- Repetitive Transcranial Magnetic Stimulation: A Potential Treatment for Obesity in Patients with Schizophrenia.Behavioral sciences (Basel, Switzerland) · 2021Review
- Automated diffusion-based parcellation of the hypothalamus reveals subunit-specific associations with obesity.Scientific reports · 2020Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
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Abstract
Dopaminergic brain structures like the nucleus accumbens (NAc) are thought to encode the incentive salience of palatable foods motivating appetitive behaviour. Animal studies have identified neural networks mediating the regulation of hedonic feeding that comprise connections of the NAc with the ventral tegmental area (VTA) and the lateral hypothalamus (LH). Here, we investigated how structural connectivity of these pathways relates to individual variability in decisions on sweet food consumption in humans. We therefore combined probabilistic tractography on diffusion imaging data from 45 overnight fasted lean to overweight participants with real decisions about high and low sugar food consumption. Across all individuals, sugar preference and connectivity strength were not directly related, however, multiple regression analysis revealed interaction of mesolimbic structure and sugar preference to depend on individuals' BMI score. In overweight individuals (BMI: ≥25 kg/m², N = 22) higher sugar preference was thereby specifically related to stronger connectivity within the VTA-NAc pathway while the opposite pattern emerged in participants with normal BMI (BMI: <25 kg/m², N = 23). Our structural results complement previous functional findings on the critical role of the human mesolimbic system for regulating hedonic eating in overweight individuals.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.