ArticleScientific reports2019
The Impact of Early Life Stress on Anxiety Symptoms in Late Adulthood.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
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Who cites it
53 citing papers in PubMed.
- Cognitive-Behavioral Intervention for Children With Hematological Cancer Receiving Chemotherapy: A Randomized Controlled Trial.Psycho-oncology · 2025Trial
- Early life predictors of subjective cognitive function in older age: emerging longitudinal associations over 6 decades.The journals of gerontology. Series B, Psychological sciences and social sciences · 2026Article
- Multilevel Effects of Socioeconomic Factors on the Somatic Status of Contemporary Youth Across Russian Regions.American journal of human biology : the official journal of the Human Biology Council · 2026Article
- Aversive 22-kHz ultrasonic vocalization playback reveals differences in affective (dys)function following early life adversity in male and female juvenile rats.Behavioural brain research · 2026Article
- Maternal separation increases anxiety-like phenotypes, fear responses, and altersNeurobiology of stress · 2026Article
- Neurodevelopmental effects of early life stress: PFC and cognition.Neuroscience and biobehavioral reviews · 2026Review
- Early life chronic stress-disrupted activity of the dorsal raphe nucleus selectively drives behavioral impairments.Communications biology · 2026Article
- A network analysis of lifetime stressor exposure, mental health, well-being, and immune cell mobilisation to acute stressors in young adults.Brain, behavior, & immunity - health · 2026Article
- Prolonged Grief-Related Symptoms Among Young Individuals After Loss of a Parent or Sibling to Cancer: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2026Review
- Maternal separation disrupts noradrenergic control of adult coping behaviors.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- Both childhood and adult perceived financial strain impact age trajectories of change in emotional health in late adulthood.Aging & mental health · 2025Observational
- Characterizing the role of early life factors in machine learning-based multimorbidity risk prediction.PLOS digital health · 2025Article
- Inflammation and minority stress: A moderated mediation model of childhood adversity and mental health in young men who have sex with men.Social science & medicine (1982) · 2025Article
- Five hypothesized biological mechanisms linking adverse childhood experiences with anxiety, depression, and PTSD: A scoping review.Neuroscience and biobehavioral reviews · 2025Article
- Association between school bullying and late-life depression: Evidence from the China health and retirement longitudinal study.Geriatrics & gerontology international · 2025Article
- Is the Relationship Between Adolescent Social Isolation and Anxiety-Like Behaviors Altered by Microglia Ablation in Female Long Evans Rats?Brain and behavior · 2025Article
- I "Gut" Rhythm: the microbiota as a modulator of the stress response and circadian rhythms.The FEBS journal · 2025Review
- The effects of childhood adversity on twenty-five disease biomarkers and twenty health conditions in adulthood: Differences by sex and stressor type.Brain, behavior, and immunity · 2025Article
- Weathering the storm: youth vulnerability and resilience during the climate crisis.npj climate action · 2025Article
- Interactions of the CSF3R polymorphism and early stress on future orientation: evidence for the differential model of stress-related growth.Epidemiology and psychiatric sciences · 2024Article
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10 authors.
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Abstract
Early life stress (ELS) may increase the risk of anxiety throughout the life course. Whether this effect extends to late adulthood is poorly known. In our study comprising 1872 participants from the Helsinki Birth Cohort Study born in 1934-1944, we investigated the association of various forms of ELS and their accumulation with self-reported anxiety symptoms at the age of 65-77 years. Data on childhood socioeconomic status and separation from parents were based on national registers for all participants. Information on self-reported emotional and physical trauma, parental divorce, and death of a family member in childhood was obtained from 1277 participants. We found that experiencing emotional trauma, physical trauma, and low socioeconomic status in childhood were associated with increased anxiety symptoms in late adulthood [B = 0.44 (95% CI = 0.31-0.58); B = 0.33 (95% CI = 0.20-0.46); B = 0.10 (95% CI = 0.01-0.19), respectively]. These associations remained significant even after controlling for other forms of ELS. Accumulation of early life stress also increased the levels of late-adulthood anxiety symptoms and the risk of anxiety regarded as clinically significant. Screening for potentially stressful childhood experiences in elderly populations may help identifying individuals with increased anxiety symptoms and planning preventive and therapeutic interventions for those exposed to ELS.
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