Evidence map›Paper›PMID 30867420›Full record

ArticleNature communications2019

Amyloid β oligomers suppress excitatory transmitter release via presynaptic depletion of phosphatidylinositol-4,5-bisphosphate.

Yang He, Mengdi Wei, Yan Wu, Huaping Qin, Weinan Li, Xiaolin Ma, Jingjing Cheng, Jinshuai Ren, Ye Shen, Zhong Chen and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 85 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
85citing papers in PubMed, 1 pooled it
12.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

85 citing papers in PubMed, 1 synthesis or guideline pooled it, 160 citations in OpenAlex.

  1. Pooled it
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  16. CaCell reports · 2025
    Article
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25 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Yang HeDepartment of Neurobiology, and Department of Ophthalmology of the First Affiliated Hospital, NHC and CAMS Key Laboratory of Medical Neurobiology, Zhejiang University School of Medicine, Hangzhou, 310058, China.
Mengdi WeiDepartment of Neurobiology, and Department of Ophthalmology of the First Affiliated Hospital, NHC and CAMS Key Laboratory of Medical Neurobiology, Zhejiang University School of Medicine, Hangzhou, 310058, China.
Yan WuDepartment of Neurobiology, and Department of Ophthalmology of the First Affiliated Hospital, NHC and CAMS Key Laboratory of Medical Neurobiology, Zhejiang University School of Medicine, Hangzhou, 310058, China.
Huaping QinDepartment of Neurobiology, and Department of Ophthalmology of the First Affiliated Hospital, NHC and CAMS Key Laboratory of Medical Neurobiology, Zhejiang University School of Medicine, Hangzhou, 310058, China.
Weinan LiDepartment of Neurobiology, and Department of Ophthalmology of the First Affiliated Hospital, NHC and CAMS Key Laboratory of Medical Neurobiology, Zhejiang University School of Medicine, Hangzhou, 310058, China.
Xiaolin MaDepartment of Neurobiology, and Department of Ophthalmology of the First Affiliated Hospital, NHC and CAMS Key Laboratory of Medical Neurobiology, Zhejiang University School of Medicine, Hangzhou, 310058, China.
Jingjing ChengDepartment of Neurobiology, and Department of Ophthalmology of the First Affiliated Hospital, NHC and CAMS Key Laboratory of Medical Neurobiology, Zhejiang University School of Medicine, Hangzhou, 310058, China.
Jinshuai RenDepartment of Neurobiology, and Department of Ophthalmology of the First Affiliated Hospital, NHC and CAMS Key Laboratory of Medical Neurobiology, Zhejiang University School of Medicine, Hangzhou, 310058, China.
Ye ShenDepartment of Neurobiology, and Department of Ophthalmology of the First Affiliated Hospital, NHC and CAMS Key Laboratory of Medical Neurobiology, Zhejiang University School of Medicine, Hangzhou, 310058, China.
Zhong ChenDepartment of Pharmacology, NHC and CAMS Key Laboratory of Medical Neurobiology, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, 310058, China.
Binggui SunDepartment of Neurobiology, and Department of Ophthalmology of the First Affiliated Hospital, NHC and CAMS Key Laboratory of Medical Neurobiology, Zhejiang University School of Medicine, Hangzhou, 310058, China.ORCID http://orcid.org/0000-0002-0386-6569
Fu-De HuangCenter for Stem Cell and NanoMedicine, Laboratory for System Biology, Shanghai Advanced Research Institute, Chinese Academy of Sciences, Shanghai, 201210, China. huangfd@sari.ac.cn.
Yi ShenDepartment of Neurobiology, and Department of Ophthalmology of the First Affiliated Hospital, NHC and CAMS Key Laboratory of Medical Neurobiology, Zhejiang University School of Medicine, Hangzhou, 310058, China. yshen2@zju.edu.cn.ORCID http://orcid.org/0000-0001-5072-4734
Yu-Dong ZhouDepartment of Neurobiology, and Department of Ophthalmology of the First Affiliated Hospital, NHC and CAMS Key Laboratory of Medical Neurobiology, Zhejiang University School of Medicine, Hangzhou, 310058, China. yudongzhou@zju.edu.cn.ORCID http://orcid.org/0000-0002-6364-3869
Zhejiang University · CNZhejiang Chinese Medical University · CNChinese Academy of Sciences · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Amyloid β (Aβ) oligomer-induced aberrant neurotransmitter release is proposed to be a crucial early event leading to synapse dysfunction in Alzheimer's disease (AD). In the present study, we report that the release probability (Pr) at the synapse between the Schaffer collateral (SC) and CA1 pyramidal neurons is significantly reduced at an early stage in mouse models of AD with elevated Aβ production. High nanomolar synthetic oligomeric Aβ

Indexed as

Alzheimer DiseaseAmyloid beta-PeptidesAnimalsCA1 Region, HippocampalCognitionDisease Models, AnimalEmbryo, MammalianHumansMaleMaze LearningMemoryMiceMice, TransgenicPeptide FragmentsPhosphatidylinositol 4,5-DiphosphatePresenilin-1Amyloid beta-Peptidesamyloid beta-protein (1-42)Grm5 protein, mousePeptide FragmentsPhosphatidylinositol 4,5-DiphosphatePresenilin-1presenilin 1, mouseReceptor, Metabotropic Glutamate 5

Identifiers

PMID30867420
PMCPMC6416269
OpenAlexW2920830526

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.