ArticleAging2019
Influence of rapid eye movement sleep on all-cause mortality: a community-based cohort study.
Article in Aging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00005275 (The Sleep Heart Health Study), which is not on this map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Sleep Heart Health Study (SHHS) Was a Multi-site Prospective Cohort Study to Investigate Obstructive Sleep Apnea (OSA) and Other Sleep-disordered Breathing (SDB) as Risk Factors for Cardiovascular Diseases and Hypertension
Who cites it
16 citing papers in PubMed, 26 citations in OpenAlex.
- Article
- Research on Large Endothelial Cell-Derived Extracellular Vesicles in Pediatric Obstructive Sleep Apnea Syndrome.Nature and science of sleep · 2026Article
- Chronic Insomnia and Stroke Risk-A Real Bidirectional Issue.Life (Basel, Switzerland) · 2025Review
- Association of Novel Sleep EEG Biomarkers with All-Cause Mortality in a Large Community-Based Cohort.Nature and science of sleep · 2025Article
- Sleep-disordered breathing increases mortality in patients with diabetes.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2025Observational
- Nocturnal oxygen saturation is associated with all-cause mortality: a community-based study.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2024Article
- Beyond sleep duration: protocol for a systematic review of multidimensional sleep health in relation to cardiovascular disease and mortality.Frontiers in sleep · 2024Article
- A prospective study of the association of weekend catch-up sleep and sleep duration with mortality in middle-aged adults.Sleep and biological rhythms · 2023Article
- The independent and combined association of napping and night sleep duration with stroke in Chinese rural adults.Sleep & breathing = Schlaf & Atmung · 2023Article
- Comparison of the usability of an automatic sleep staging program via portable 1-channel electroencephalograph and manual sleep staging with traditional polysomnography.Sleep and biological rhythms · 2023Article
- Sleep architecture of short sleep time in patients with obstructive sleep apnea: a retrospective single-facility study.Sleep & breathing = Schlaf & Atmung · 2022Article
- Preoperative REM sleep is associated with complication development after colorectal surgery.Surgical endoscopy · 2022Observational
- Mortality associated with nonrestorative short sleep or nonrestorative long time-in-bed in middle-aged and older adults.Scientific reports · 2022Article
- Increased Rapid Eye Movement Sleep Is Associated With a Reduced Risk of Heart Failure in Middle-Aged and Older Adults.Frontiers in cardiovascular medicine · 2022Article
- Physiological sleep measures predict time to 15-year mortality in community adults: Application of a novel machine learning framework.Journal of sleep research · 2021Article
- Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionAlthough the proportion and duration of rapid eye movement (REM) sleep are correlated with neurological and cardiovascular diseases, whether REM sleep is associated with all-cause mortality in community-based populations remains unknown.
methodsA prospective study was performed within the Sleep Heart Health Study (SHHS, Registration NO. NCT00005275). Total sleep time, sleep efficiency, and REM sleep were measured using polysomnography. Cox proportional hazards regression models were used to estimate the association of the REM sleep with all-cause mortality.
resultsOver a mean follow-up period of 11.0 ± 3.1 y, 1234 individuals (21.9%) died. In the entire population, reduced REM sleep was significantly associated with increasing all-cause mortality. After adjustment for age, sex, race, body mass index, smoking status, total cholesterol, triglycerides, high-density lipoprotein, history of diabetes and hypertension, and the apnea-hypopnea index, the duration and proportion of REM sleep were found to be significantly associated with all-cause mortality when the lowest and the highest REM quartile groups were compared (hazard ratio, 95% confidence interval: 1.727, 1.434-2.079; 1.545, 1.298-1.839; respectively).
conclusionThe proportion and duration of REM sleep are negatively associated with all-cause mortality. This finding emphasizes the importance of personalized sleep management in community-based populations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.