Evidence map›Paper›PMID 30867328›Full record

ArticlemSphere2019

Spatial and Temporal Analysis of the Stomach and Small-Intestinal Microbiota in Fasted Healthy Humans.

Anna M Seekatz, Matthew K Schnizlein, Mark J Koenigsknecht, Jason R Baker, William L Hasler, Barry E Bleske, Vincent B Young, Duxin Sun

Open access · goldAbstract read
In one paragraph

Article in mSphere, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed, 2 pooled it
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

59 citing papers in PubMed, 2 syntheses or guidelines pooled it, 96 citations in OpenAlex.

  1. Pooled it
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  15. Review
  16. Quantifying compositional variability in microbial communities with FAVA.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  17. Article
  18. Review
  19. Role of the Small Intestinal Microbiota in Gastrointestinal Disorders.The Korean journal of helicobacter and upper gastrointestinal research · 2024
    Review
  20. Heliyon · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Anna M Seekatz *Department of Internal Medicine, Division of Infectious Disease, University of Michigan, Ann Arbor, Michigan, USA.ORCID 0000-0003-2586-7498
Matthew K Schnizlein *Department of Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan, USA.ORCID 0000-0002-0797-8357
Mark J Koenigsknecht *Department of Internal Medicine, Division of Infectious Disease, University of Michigan, Ann Arbor, Michigan, USA.ORCID 0000-0001-8287-784X
Jason R BakerDepartment of Internal Medicine, Division of Gastroenterology and Hepatology, University of Michigan, Ann Arbor, Michigan, USA.
William L HaslerDepartment of Internal Medicine, Division of Gastroenterology and Hepatology, University of Michigan, Ann Arbor, Michigan, USA.ORCID 0000-0002-6158-2871
Barry E BleskeDepartment of Pharmacy Practice and Administrative Sciences, University of New Mexico, Albuquerque, New Mexico, USA.ORCID 0000-0002-4299-0829
Vincent B YoungDepartment of Internal Medicine, Division of Infectious Disease, University of Michigan, Ann Arbor, Michigan, USA youngvi@umich.edu duxins@umich.edu.ORCID 0000-0003-3687-2364
Duxin SunDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, Michigan, USA youngvi@umich.edu duxins@umich.edu.
University of Michigan · USUniversity of New Mexico · US

Funding

Michigan Institute for Clinical and Health Research (MICHR)UL1TR002240 · NCATS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LUMENG, JULIE C, MASHOUR, GEORGE ALEXANDER · 2017 to 2022
$54.9M
Michigan Institute for Clinical and Health Research (MCHR)UL1TR000433 · NCATS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MASHOUR, GEORGE ALEXANDER · 2012 to 2016
$49.9M
Systems biology of Clostridium difficile infectionU01AI124255 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SCHLOSS, PATRICK DAVID, YOUNG, VINCENT B · 2016 to 2020
$9.8M
NCATS NIH HHS UL1 TR000433NCATS NIH HHS UL1 TR002240NIAID NIH HHS U01 AI124255
6 · The paper itself

Abstract

Although the microbiota in the proximal gastrointestinal (GI) tract have been implicated in health and disease, much about these microbes remains understudied compared to those in the distal GI tract. This study characterized the microbiota across multiple proximal GI sites over time in healthy individuals. As part of a study of the pharmacokinetics of oral mesalamine administration, healthy, fasted volunteers (

Indexed as

FastingGastrointestinal MicrobiomeAdministration, OralAdolescentAdultBacillotaBacteriaFecesFemaleHealthy VolunteersHumansHydrogen-Ion ConcentrationIntestine, SmallIntubation, GastrointestinalLinear ModelsMaleRNA, Ribosomal, 16SmesalaminemicrobiotapHsmall intestinestomach

Identifiers

PMID30867328
PMCPMC6416366
OpenAlexW2898205982

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.