ArticleScience translational medicine2019
A gastric resident drug delivery system for prolonged gram-level dosing of tuberculosis treatment.
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Article in Science translational medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20citing papers in PubMed
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20 citing papers in PubMed, 50 citations in OpenAlex.
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- Modular Titratable Polypills for Personalized Medicine and Simplification of Complex Medication Regimens.Advanced healthcare materials · 2023Article
- Enzyme-Triggered Intestine-Specific Targeting Adhesive Platform for Universal Oral Drug Delivery.Advanced healthcare materials · 2023Article
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- Foundations of gastrointestinal-based drug delivery and future developments.Nature reviews. Gastroenterology & hepatology · 2022Review
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- Engineered drug delivery devices to address Global Health challenges.Journal of controlled release : official journal of the Controlled Release Society · 2021Review
- A Long-Acting Thermoresponsive Injectable Formulation of Tin Protoporphyrin Sustains Antitubercular Efficacy in a Murine Infection Model.ACS pharmacology & translational science · 2021Article
- A New Long-Term Composite Drug Delivery System Based on Thermo-Responsive Hydrogel and Nanoclay.Nanomaterials (Basel, Switzerland) · 2020Article
- Gastrointestinal-resident, shape-changing microdevices extend drug release in vivo.Science advances · 2020Article
- Development of a long-acting direct-acting antiviral system for hepatitis C virus treatment in swine.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Leveraging Computational Modeling to Understand Infectious Diseases.Current pathobiology reports · 2020Review
- In Vitro and In Vivo Test Methods for the Evaluation of Gastroretentive Dosage Forms.Pharmaceutics · 2019Review
- Untethered shape-changing devices in the gastrointestinal tract.Expert opinion on drug deliveryReview
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Authors and funding
49 authors at 13 institutions in 3 countries.
Malvika VermaDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.ORCID 0000-0001-7043-5120
Karan VishwanathKoch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.ORCID 0000-0003-2910-9176
Feyisope EwejeKoch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Niclas RoxhedKoch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.ORCID 0000-0002-7147-6730
Tyler GrantKoch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Macy CastanedaKoch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Christoph SteigerKoch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.ORCID 0000-0002-5994-7819
Hormoz MazdiyasniKoch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.ORCID 0000-0003-1725-0877
Taylor BenselKoch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Daniel MinahanKoch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.ORCID 0000-0003-3065-055X
Vance SoaresKoch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.ORCID 0000-0002-4094-3316
John A F SalamaKoch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Aaron LopesKoch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Kaitlyn HessKoch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.ORCID 0000-0003-2837-0305
Cody ClevelandKoch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.ORCID 0000-0002-2973-8530
Daniel J FulopKoch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.ORCID 0000-0003-1964-4861
Alison HaywardKoch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.ORCID 0000-0002-9581-8563
Joy CollinsKoch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.ORCID 0000-0002-9232-4517
Siddartha M TamangKoch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Tiffany HuaKoch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Chinonyelum IkeanyiKoch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Gal ZeidmanKoch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.ORCID 0000-0002-9888-489X
Elizabeth MuleKoch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.ORCID 0000-0002-0081-3971
Sooraj BoominathanKoch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Ellena PopovaKoch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.ORCID 0000-0002-9624-0628
Jonathan B MillerDepartment of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.ORCID 0000-0003-4610-0210
Andrew M BellingerKoch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
David CollinsManagement Sciences for Health, Medford, MA 02155, USA.ORCID 0000-0002-4327-5907
Dalia LeibowitzTata Center for Technology and Design, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Shelly BatraOperation ASHA, New Delhi 110076, India.
Sandeep AhujaOperation ASHA, New Delhi 110076, India.
Manju BajiyaOperation ASHA, New Delhi 110076, India.
Sonali BatraOperation ASHA, New Delhi 110076, India.ORCID 0000-0003-2921-9295
Rohit SarinNational Institute of Tuberculosis and Respiratory Diseases, New Delhi 110030, India.
Upasna AgarwalNational Institute of Tuberculosis and Respiratory Diseases, New Delhi 110030, India.
Sunil D KhapardeFormer Deputy Director General and Head of Central TB Division, Government of India, New Delhi 110011, India.
Neeraj K GuptaDepartment of Respiratory Medicine, Safdarjung Hospital, New Delhi 110029, India.
Deepak GuptaDivision of Pulmonary and Critical Care Medicine, All India Institute of Medical Sciences, New Delhi 110029, India.
Anuj K BhatnagarRajan Babu Institute for Pulmonary Medicine and Tuberculosis, New Delhi 110009, India.ORCID 0000-0002-4152-2660
Kamal K ChopraNew Delhi Tuberculosis Centre, New Delhi 110002, India.
Nandini SharmaDepartment of Community Medicine, Maulana Azad Medical College, New Delhi 110002, India.
Ashwani KhannaLok Nayak Hospital Chest Clinic, New Delhi 110002, India.
Jayeeta ChowdhuryTata Trusts, Mumbai 400001, India.
Robert StonerTata Center for Technology and Design, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Alexander H SlocumTata Center for Technology and Design, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Michael J CimaKoch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.ORCID 0000-0003-2379-6139
Jennifer FurinDepartment of Global Health and Social Medicine, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0002-0825-7199
Robert LangerDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. rlanger@mit.edu ctraverso@bwh.harvard.edu cgt20@mit.edu.ORCID 0000-0003-4255-0492
Giovanni TraversoKoch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. rlanger@mit.edu ctraverso@bwh.harvard.edu cgt20@mit.edu.ORCID 0000-0001-7851-4077
Massachusetts Institute of Technology · USAsha Foundation · INBrigham and Women's Hospital · USHarvard University · USLRS Institute of Tuberculosis and Respiratory Diseases · INNew Delhi Tuberculosis Center · INAll India Institute of Medical Sciences · INBoston University · USGovernment of India · INLok Nayak Jai Prakash Narayan Hospital · INMaulana Azad Medical College · INSafdarjang Hospital · INTata Trusts · IN
Funding
No grant is acknowledged in the PubMed record.
Abstract
Multigram drug depot systems for extended drug release could transform our capacity to effectively treat patients across a myriad of diseases. For example, tuberculosis (TB) requires multimonth courses of daily multigram doses for treatment. To address the challenge of prolonged dosing for regimens requiring multigram drug dosing, we developed a gastric resident system delivered through the nasogastric route that was capable of safely encapsulating and releasing grams of antibiotics over a period of weeks. Initial preclinical safety and drug release were demonstrated in a swine model with a panel of TB antibiotics. We anticipate multiple applications in the field of infectious diseases, as well as for other indications where multigram depots could impart meaningful benefits to patients, helping maximize adherence to their medication.
Indexed as
Drug Delivery SystemsAnimalsAnti-Bacterial AgentsAntitubercular AgentsDelayed-Action PreparationsDose-Response Relationship, DrugDoxycyclineDrug LiberationHumansStomachSwineTuberculosisAnti-Bacterial AgentsAntitubercular AgentsDelayed-Action PreparationsDoxycycline
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.