Evidence map›Paper›PMID 30867314›Full record

ArticleJournal of virology2019

The Infectious Bronchitis Coronavirus Envelope Protein Alters Golgi pH To Protect the Spike Protein and Promote the Release of Infectious Virus.

Jason W Westerbeck, Carolyn E Machamer

Open access · greenAbstract read
In one paragraph

Article in Journal of virology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed
14.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 101 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Jason W WesterbeckDepartment of Cell Biology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Carolyn E MachamerDepartment of Cell Biology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA machamer@jhmi.edu.
Johns Hopkins Medicine · USJohns Hopkins University · US

Funding

BIOCHEMISTRY, CELLULAR AND MOLECULAR BIOLOGY PROGRAMT32GM007445 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI GREEN, RACHEL · 1985 to 2021
$24.1M
Accommodation of large cargo within Golgi cisternaeR01GM117399 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI MACHAMER, CAROLYN E · 2016 to 2019
$1.4M
NIGMS NIH HHS R01 GM117399NIGMS NIH HHS T32 GM007445
6 · The paper itself

Abstract

Coronaviruses (CoVs) assemble by budding into the lumen of the early Golgi complex prior to exocytosis. The small CoV envelope (E) protein plays roles in assembly, virion release, and pathogenesis. CoV E has a single hydrophobic domain (HD), is targeted to Golgi membranes, and has cation channel activity

Indexed as

AnimalsBronchitisCell MembraneChlorocebus aethiopsCoronavirusCoronavirus Envelope ProteinsCoronavirus InfectionsGolgi ApparatusHeLa CellsHumansHydrogen-Ion ConcentrationInfectious bronchitis virusSecretory PathwaySpike Glycoprotein, CoronavirusVero CellsViral Envelope ProteinsCoronavirus Envelope Proteinsenvelope protein, SARS-CoV-2Spike Glycoprotein, CoronavirusViral Envelope ProteinscoronavirusE proteinGolgioligomerspHviroporin

Identifiers

PMID30867314
PMCPMC6532078
OpenAlexW2952383690

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.