ArticleProceedings of the National Academy of Sciences of the United States of America2019
Using a system's equilibrium behavior to reduce its energy dissipation in nonequilibrium processes.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed.
- Experimentally achieving minimal dissipation via thermodynamically optimal transport.Nature communications · 2025Article
- Optimal transitions between nonequilibrium steady states.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Stochastic Thermodynamics of a Linear Optical Cavity Driven on Resonance.ACS photonics · 2025Article
- Energetic scaling in microbial growth.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Probing complexity: thermodynamics and computational mechanics approaches to origins studies.Interface focus · 2019Article
- Co-temporal Force and Fluorescence Measurements Reveal a Ribosomal Gear Shift Mechanism of Translation Regulation by Structured mRNAs.Molecular cell · 2019Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Cells must operate far from equilibrium, utilizing and dissipating energy continuously to maintain their organization and to avoid stasis and death. However, they must also avoid unnecessary waste of energy. Recent studies have revealed that molecular machines are extremely efficient thermodynamically compared with their macroscopic counterparts. However, the principles governing the efficient out-of-equilibrium operation of molecular machines remain a mystery. A theoretical framework has been recently formulated in which a generalized friction coefficient quantifies the energetic efficiency in nonequilibrium processes. Moreover, it posits that, to minimize energy dissipation, external control should drive the system along the reaction coordinate with a speed inversely proportional to the square root of that friction coefficient. Here, we demonstrate the utility of this theory for designing and understanding energetically efficient nonequilibrium processes through the unfolding and folding of single DNA hairpins.
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