Evidence map›Paper›PMID 30867197›Full record

ArticleGenetics2019

Centrosome Loss Triggers a Transcriptional Program To Counter Apoptosis-Induced Oxidative Stress.

John S Poulton, Daniel J McKay, Mark Peifer

Open access · bronzeAbstract read
In one paragraph

Article in Genetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.8field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Novel function ofProceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  6. Mud Loss Restricts Yki-Dependent Hyperplasia inJournal of developmental biology · 2020
    Article
  7. Article
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

John S PoultonDepartment of Biology, University of North Carolina at Chapel Hill, North Carolina 27599 poultonj@email.unc.edu peifer@unc.edu.
Daniel J McKayDepartment of Biology, University of North Carolina at Chapel Hill, North Carolina 27599.
Mark PeiferDepartment of Biology, University of North Carolina at Chapel Hill, North Carolina 27599 poultonj@email.unc.edu peifer@unc.edu.
University of North Carolina at Chapel Hill · US

Funding

Regulating cell fate and shaping the body plan during morphogenesis and their alteration during oncogenesisR35GM118096 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Mark A. Peifer · 2016 to 2026
$6.5M
Genetic and epigenetic mechanisms of developmental gene regulationR35GM128851 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Daniel J McKay · 2018 to 2026
$3.9M
NIGMS NIH HHS R35 GM118096NIGMS NIH HHS R35 GM128851
6 · The paper itself

Abstract

Centrosomes play a critical role in mitotic spindle assembly through their role in microtubule nucleation and bipolar spindle assembly. Loss of centrosomes can impair the ability of some cells to properly conduct mitotic division, leading to chromosomal instability, cell stress, and aneuploidy. Multiple aspects of the cellular response to mitotic error associated with centrosome loss appear to involve activation of JNK signaling. To further characterize the transcriptional effects of centrosome loss, we compared gene expression profiles of wild-type and acentrosomal cells from

Indexed as

ApoptosisCentrosomeMAP Kinase Signaling SystemOxidative StressAnimalsDrosophilaEpithelial CellsGene Expression ProfilingMitosisSequence Analysis, RNASpindle ApparatusTranscriptional ActivationapoptosiscentrosomesJNK signalingoxidative stressROS

Identifiers

PMID30867197
PMCPMC6499520
OpenAlexW2951639897

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.