Observational studyPsychological medicine2020
Toward incorporating genetic risk scores into symptom networks of psychosis.
Observational study in Psychological medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Meta-analytic Gaussian Network Aggregation.Psychometrika · 2022Pooled it
- Hierarchical Phenotyping of Psychopathology: Implications and Opportunities for Precision Psychiatry When Biology Could Be Associated With Both Symptoms and Syndromes.Biological psychiatry · 2026Review
- Symptom Network Analysis Tools for Applied Researchers With Cross-Sectional and Panel Data - A Brief Overview and Multiverse Analysis.Psychological reports · 2025Review
- Mapping aggressive behaviors and testosterone among schizophrenia patients in acute stage.Schizophrenia (Heidelberg, Germany) · 2025Article
- Childhood Maltreatment, Bullying, and Internet Addiction in Relation to Suicidal Ideation Among Adolescents: Cross-Sectional Mediation and Network Analysis.Journal of medical Internet research · 2025Article
- Symptom network analysis of prefrontal seizures.Epilepsia · 2025Article
- Impacts of risk thresholds and age on clinical high risk for psychosis: a comparative network analysis.European archives of psychiatry and clinical neuroscience · 2025Article
- Network analysis of comorbid aggressive behavior and testosterone among bipolar disorder patients: a cross-sectional study.Translational psychiatry · 2024Article
- Networks of Adversity in Childhood and Adolescence and Their Relationship to Adult Mental Health.Research on child and adolescent psychopathology · 2023Article
- A network analysis of depressive symptoms and metabolomics.Psychological medicine · 2023Article
- Network analysis of comorbid depression, suicidality and biomarkers on HPA axis among mood disorder patients to psychiatric emergency services.Translational psychiatry · 2023Article
- Internet addiction and residual depressive symptoms among clinically stable adolescents with major psychiatric disorders during the COVID-19 pandemic: a network analysis perspective.Translational psychiatry · 2023Article
- Bridging the phenomenological gap between predictive basic-symptoms and attenuated positive symptoms: a cross-sectional network analysis.Schizophrenia (Heidelberg, Germany) · 2022Article
- Role of polygenic and environmental factors in the co-occurrence of depression and psychosis symptoms: a network analysis.Translational psychiatry · 2022Article
- Cognitive and Academic Skills in Two Developmental Cohorts of Different Ability Level: A Mutualistic Network Perspective.Journal of applied research in memory and cognition · 2022Article
- A network approach to relationships between cannabis use characteristics and psychopathology in the general population.Scientific reports · 2022Article
- Unconsidered issues of measurement noninvariance in biological psychiatry: A focus on biological phenotypes of psychopathology.Molecular psychiatry · 2022Review
- Autistic Symptoms and Social Functioning in Psychosis: A Network Approach.Schizophrenia bulletin · 2022Article
- Understanding the Association Between Intolerance of Uncertainty and Problematic Smartphone Use: A Network Analysis.Frontiers in psychiatry · 2022Article
- Do the core symptoms play key roles in the development of problematic smartphone use symptoms.Frontiers in psychiatry · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPsychosis spectrum disorder is a heterogeneous, multifactorial clinical phenotype, known to have a high heritability, only a minor portion of which can be explained by molecular measures of genetic variation. This study proposes that the identification of genetic variation underlying psychotic disorder may have suffered due to issues in the psychometric conceptualization of the phenotype. Here we aim to open a new line of research into the genetics of mental disorders by explicitly incorporating genes into symptom networks. Specifically, we investigate whether links between a polygenic risk score (PRS) for schizophrenia and measures of psychosis proneness can be identified in a network model.
methodsWe analyzed data from n = 2180 subjects (controls, patients diagnosed with a non-affective psychotic disorder, and the first-degree relatives of the patients). A network structure was computed to examine associations between the 42 symptoms of the Community Assessment of Psychic Experiences (CAPE) and the PRS for schizophrenia.
resultsThe resulting network shows that the PRS is directly connected to the spectrum of positive and depressive symptoms, with the items conspiracy and no future being more often located on predictive pathways from PRS to other symptoms.
conclusionsTo our knowledge, the current exploratory study provides a first application of the network framework to the field of behavior genetics research. This allows for a novel outlook on the investigation of the relations between genome-wide association study-based PRSs and symptoms of mental disorders, by focusing on the dependencies among variables.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.