Evidence map›Paper›PMID 30867061›Full record

ArticleStem cell research & therapy2019

Intraarticular senescent chondrocytes impair the cartilage regeneration capacity of mesenchymal stem cells.

Xu Cao, Pan Luo, Junjie Huang, Chi Liang, Jinshen He, Zili Wang, Dongyong Shan, Cheng Peng, Song Wu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cell research & therapy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Xu CaoDepartment of Orthopaedics of the 3rd Xiangya Hospital, Central South University, Changsha, 410013, China.
Pan LuoDepartment of Orthopaedics of the 3rd Xiangya Hospital, Central South University, Changsha, 410013, China.
Junjie HuangDepartment of Orthopaedics of the 3rd Xiangya Hospital, Central South University, Changsha, 410013, China.
Chi LiangDepartment of Orthopaedics of the 3rd Xiangya Hospital, Central South University, Changsha, 410013, China.
Jinshen HeDepartment of Orthopaedics of the 3rd Xiangya Hospital, Central South University, Changsha, 410013, China.
Zili WangDepartment of Orthopaedics of the 3rd Xiangya Hospital, Central South University, Changsha, 410013, China.
Dongyong ShanDepartment of Oncology of the 3rd Xiangya Hospital, Central South University, Changsha, China.
Cheng PengDepartment of Burns and Plastic Surgery of the 3rd Xiangya Hospital, Central South University, Changsha, 410013, China. pcheng83@sina.com.
Song WuDepartment of Orthopaedics of the 3rd Xiangya Hospital, Central South University, Changsha, 410013, China. xy3ws1969@hotmail.com.
Xiangya Hospital Central South University · CNCentral South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSenescent cells exert a significant influence over their surrounding cellular environment. Senescent chondrocytes (SnChos) were found to be accumulated in degenerated cartilage present in joints affected by osteoarthritis. The influence of SnChos on exogenously transplanted stem cells has yet to be reported.

methodsIn this study, we evaluated the interactions between SnChos and bone marrow mesenchymal stem cells (BMSCs) when co-cultured as well as in the intra-articular senescent microenvironment (IASM). The effect of IASM on cartilage regeneration was also assessed.

resultsIt was found that a small fraction of SnChos induced BMSC cellular senescence and apoptosis. SnChos also inhibited proliferation, facilitated stemness, and suppressed chondrogenic differentiation of BMSCs. BMSCs induced the apoptosis of SnChos, reduced the proportion of SnChos, stimulated SnChos proliferation, and revealed a bidirectional effect on SnChos inflammaging. IASM significantly suppressed the survival, proliferation, and appropriate differentiation of grafted BMSCs in vivo, all of which impaired cartilage regeneration. Anti-senescence agent ABT-263 was able to partly rescue the cells from the negative effects of SnChos.

conclusionsThe SnChos and BMSCs interacted with each other at cellular senescence, apoptosis, proliferation, differentiation, and cell functions. This interaction impaired the cartilage repair of MSCs. Anti-senescence agent provided a possible solution for this impairment.

Indexed as

Cellular SenescenceRegenerationAnimalsCartilageChondrocytesCoculture TechniquesMaleMesenchymal Stem CellsRatsRats, Sprague-DawleyBone marrow mesenchymal stem cells (BMSCs)Cartilage repairIntra-articular senescent microenvironment (IASM)Osteoarthritis (OA)Senescent chondrocytes (SnChos)

Identifiers

PMID30867061
PMCPMC6416972
OpenAlexW2926052520

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.