ArticleParasites & vectors2019
Infection with Trichomonas vaginalis increases the risk of psychiatric disorders in women: a nationwide population-based cohort study.
Article in Parasites & vectors, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 36 citations in OpenAlex.
- Vaginal Microbiome: Environmental, Biological, and Racial Influences on Gynecological Health Across the Lifespan.American journal of reproductive immunology (New York, N.Y. : 1989) · 2024Review
- Probiotics and Fecal Microbiota Transplantation in Major Depression: Doxa or Episteme?Advances in experimental medicine and biology · 2024Review
- A fluorescence-based assay for Trichomonas vaginalis drug screening.Parasites & vectors · 2023Article
- Examining the Relationships between the Incidence of Infectious Diseases and Mood Disorders: An Analysis of Data from the Global Burden of Disease Studies, 1990-2019.Diseases (Basel, Switzerland) · 2023Article
- Locust Bean Gum Nano-Based Hydrogel for Vaginal Delivery of Diphenyl Diselenide in the Treatment of Trichomoniasis: Formulation Characterization and In Vitro Biological Evaluation.Pharmaceutics · 2022Article
- Association between trichomoniasis and prostate and bladder diseases: a population-based case-control study.Scientific reports · 2022Article
- Induction of apoptosis by hydroalcoholic and methanolic extract ofJournal of parasitic diseases : official organ of the Indian Society for Parasitology · 2022Article
- Infection withParasitology · 2020Article
- Association between Trichomonas vaginalis infection and cervical lesions: a population-based, nested case-control study in Taiwan.Parasitology research · 2020Article
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundTrichomonas vaginalis is a protozoan parasite that causes trichomoniasis and annually infects approximately 276 million people worldwide. We observed an ambiguously higher probability of trichomoniasis in patients from the psychiatric department of Tri-Service General Hospital. Herein, we aimed to investigate the association between trichomoniasis and the risk of developing psychiatric disorders.
methodsThe nationwide population-based study utilized the database of the National Health Insurance (NHI) programme in Taiwan. A total of 46,865 subjects were enrolled in this study from 2000-2013, comprising 9373 study subjects with trichomoniasis and 37,492 subjects without trichomoniasis as the control group. Cox proportional hazards regression analysis was performed to calculate the hazard ratio (HR) of psychiatric disorders during the 14 years of follow-up.
resultsOf the study subjects with trichomoniasis, 875 (9.34%) developed psychiatric disorders compared with 1988 (5.30%) in the control group (P < 0.001). The adjusted hazard ratio (aHR) of overall psychiatric disorders in the study subjects was 1.644 (95% confidence interval, CI: 1.514-1.766; P < 0.001). More specifically, the study subjects had a higher risk for developing an individual psychiatric disorder, including depression, anxiety, bipolar disorder, schizophrenia and substance abuse. Although metronidazole treatment reduced the risk for developing several subgroups of psychiatric disorders, significant reduction was detected for depression only. Furthermore, refractory trichomoniasis (trichomoniasis visits ≥ 2) enhanced the risk of psychiatric disorders.
conclusionsWe show herein that T. vaginalis infection increases the overall risk for psychiatric disorders. The novel role of T. vaginalis in developing psychiatric disorders deserves more attention, and the control of such a neglected pathogen is of urgent public health importance.
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