Evidence map›Paper›PMID 30867033›Full record

ArticleParasites & vectors2019

Insecticide resistance modifies mosquito response to DEET and natural repellents.

Emilie Deletre, Thibaud Martin, Claire Duménil, Fabrice Chandre

Open access · goldAbstract read
In one paragraph

Article in Parasites & vectors, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 1 pooled it
8.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 1 synthesis or guideline pooled it, 78 citations in OpenAlex.

  1. Pooled it
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  17. High-throughput behavioral phenotyping of tiny arthropods: Chemosensory traits in a mesostigmatic hematophagous mite.Journal of experimental zoology. Part A, Ecological and integrative physiology · 2023
    Article
  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Emilie DeletreCirad - Montpellier University - UPR Hortsys, Montpellier, France. emilie.deletre@cirad.fr.ORCID http://orcid.org/0000-0001-7755-7585
Thibaud MartinCirad - Montpellier University - UPR Hortsys, Montpellier, France.
Claire DuménilCirad - Montpellier University - UPR Hortsys, Montpellier, France.
Fabrice ChandreUMR MIVEGEC, IRD-CNRS-Montpellier University, Montpellier, France.
Centre de Coopération Internationale en Recherche Agronomique pour le Développement · FRCentre National de la Recherche Scientifique · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPyrethroid and organophosphate resistance in the malaria vector Anopheles gambiae has led to the search for not only alternative insecticides, but also repellent chemical compounds. However, little is known about the potential actions of repellents and the cross-resistance risk between insecticide and repellent compounds.

methodsHere we show the action of permethrin, DEET, geraniol, carvacrol, culminaldehyde and cinnamaldehyde against three A. gambiae strains: 'Kis' (Kisumu susceptible strain), 'KdrKis' (pyrethroid resistant strain) and 'AcerKis' (organophosphate resistant strain), the last two differing from the first by a mutation on the kdr and ace1 genes, respectively.

conclusionsResults from the DEET assays show it induced repellency for the resistant KdrKis and AcerKis strains but maintained irritancy for the susceptible strain. More generally, we show resistance genes modify the behavior of An. gambiae, increasing or decreasing the effectiveness of DEET and natural compounds, depending on the mutation. These findings offer a new avenue for research on the target and mechanism of repellent compounds. We discuss these findings in the context of vector control strategies.

Indexed as

Insecticide ResistanceMosquito ControlAcroleinAcyclic MonoterpenesAnimalsAnophelesCymenesDEETFemaleHumansInsecticidesInsect RepellentsMalariaMaleMonoterpenesMosquito VectorsAcroleinAcyclic MonoterpenescarvacrolcinnamaldehydeCymenesDEETgeraniolInsecticidesInsect RepellentsMonoterpenesPermethrinPyrethrinsTerpenesAnopheles gambiaeCinnamaldehydeDeterrentGeraniolMortalityPermethrin

Identifiers

PMID30867033
PMCPMC6417241
OpenAlexW2942147228

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.