ArticleParasites & vectors2019
First dengue virus seroprevalence study on Madeira Island after the 2012 outbreak indicates unreported dengue circulation.
Article in Parasites & vectors, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Direct Infection of B Cells by Dengue Virus Modulates B Cell Responses in a Cambodian Pediatric Cohort.Frontiers in immunology · 2020Trial
- Detection of dengue virus serotype 2 in local Aedes aegypti populations, Madeira Island, Portugal, 2025.Parasites & vectors · 2026Article
- Dengue epidemic in China before 1978.Infectious diseases of poverty · 2024Review
- Phylodynamics unveils invading and diffusing patterns of dengue virus serotype-1 in Guangdong, China from 1990 to 2019 under a global genotyping framework.Infectious diseases of poverty · 2024Article
- Preliminary results on an autochthonous dengue outbreak in Lombardy Region, Italy, August 2023.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2023Article
- Comparing the performance of dengue virus IgG and IgG-capture enzyme-linked immunosorbent assays in seroprevalence study.BMC infectious diseases · 2023Article
- A unified global genotyping framework of dengue virus serotype-1 for a stratified coordinated surveillance strategy of dengue epidemics.Infectious diseases of poverty · 2022Article
- Article
- Long-term shedding of viable SARS-CoV-2 in kidney transplant recipients with COVID-19.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2021Article
- [Intensified epidemiological surveillance of arbovirosis: First case of native dengue fever in Catalonia (Spain), Northern Metropolitan Area of Barcelona, 2018-2019].Atencion primaria · 2021Observational
- Risk of dengue virus infection according to serostatus in individuals from dengue endemic areas of Mexico.Scientific reports · 2020Article
- Dengue and Zika Viruses: Epidemiological History, Potential Therapies, and Promising Vaccines.Tropical medicine and infectious disease · 2020Review
- Comparison of Japanese Encephalitis Force of Infection in Pigs, Poultry and Dogs in Cambodian Villages.Pathogens (Basel, Switzerland) · 2020Article
- Serological Evidence for Japanese Encephalitis and West Nile Virus Infections in Domestic Birds in Cambodia.Frontiers in veterinary science · 2020Article
- Emerging Aedes-borne infections in southern Switzerland: Preparedness planning for surveillance and intervention.Travel medicine and infectious diseaseArticle
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11 authors.
Funding
Abstract
backgroundIn 2012, the first dengue virus outbreak was reported on the Portuguese island of Madeira with 1080 confirmed cases. Dengue virus of serotype 1 (DENV-1), probably imported from Venezuela, caused this outbreak with autochthonous transmission by invasive Aedes aegypti mosquitoes.
resultsWe investigated the seroprevalence among the population on Madeira Island four years after the outbreak. Study participants (n = 358), representative of the island population regarding their age and gender, were enrolled in 2012 in a cross-sectional study. Dengue antibodies were detected with an in-house enzyme-linked immunosorbent assay (ELISA) using the dimer of domain III (ED3) of the DENV-1 envelope protein as well as commercial Panbio indirect and capture IgG ELISAs. Positive ELISA results were validated with a neutralization test. The overall seroprevalence was found to be 7.8% (28/358) with the in-house ELISA, whereas the commercial DENV indirect ELISA detected IgG antibodies in 8.9% of the individuals (32/358). The results of the foci reduction neutralization test confirmed DENV-1 imported from South America as the causative agent of the 2012 epidemic. Additionally, we found a higher seroprevalence in study participants with an age above 60 years old and probable secondary DENV infected individuals indicating unreported dengue circulation before or after 2012 on Madeira Island.
conclusionsThis study revealed that the number of infections might have been much higher than estimated from only confirmed cases in 2012/2013. These mainly DENV-1 immune individuals are not protected from a secondary DENV infection and the majority of the population of Madeira Island is still naïve for DENV. Surveillance of mosquitoes and arboviruses should be continued on Madeira Island as well as in other European areas where invasive vector mosquitoes are present.
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