ArticleRespiratory research2019
Body composition, muscle function, and physical performance in fibrotic interstitial lung disease: a prospective cohort study.
Article in Respiratory research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 4 of them syntheses that pooled it.
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Who cites it
41 citing papers in PubMed, 4 syntheses or guidelines pooled it, 71 citations in OpenAlex.
- Low muscle mass in interstitial lung disease: a systematic review and meta-analysis of prevalence and clinical associations.BMC pulmonary medicine · 2026Pooled it
- Benefits of different characteristics of pulmonary rehabilitation programs in patients with interstitial lung disease: a systematic review and meta-analysis.Annals of medicine · 2025Pooled it
- Sarcopenia in idiopathic pulmonary fibrosis: an updated systematic review and meta-analysis.Frontiers in medicine · 2025Pooled it
- Prevalence and assessment of frailty in interstitial lung disease - a systematic review and meta-analysis.Chronic respiratory diseasePooled it
- Review of the Impact of Weight Loss and Body Mass Index in Clinical Trials of Nintedanib in Interstitial Lung Disease.Advances in therapy · 2026Article
- Locomotor muscle dysfunction and rehabilitative exercise training in fibrotic interstitial lung disease: Where are we at and where could we go?Experimental physiology · 2026Review
- Sex Differences in Muscle-Respiratory Function Relationship in Lung Transplant Patients: A Longitudinal Study.Journal of cachexia, sarcopenia and muscle · 2026Article
- Molecular and Structural Changes, and Skeletal Muscle Strength and Endurance in Chronic Obstructive Pulmonary Disease and Interstitial Lung Disease: Practical Applications of Assessment and Management.Bioengineering (Basel, Switzerland) · 2026Review
- Analysis of body composition with bioelectrical impedance analysis in different subtypes of pulmonary fibrosis.Scientific reports · 2026Article
- Frailty and functional outcomes in patients with progressive fibrosing interstitial lung diseases receiving antifibrotic therapy: a real-life observational study.Frontiers in medicine · 2026Article
- Does body composition matter in patients with systemic sclerosis?Rheumatology (Oxford, England) · 2025Article
- Body composition, maximal fitness, and submaximal exercise function in people with interstitial lung disease.Respiratory research · 2025Article
- The DSC Index: A new prognostic tool for evaluating functional status in interstitial lung disease.Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG · 2025Article
- Characteristics and Impact of Peripheral and Respiratory Muscle Weakness in Patients With Interstitial Lung Disease: A Cross-Sectional Observational Study.Canadian respiratory journal · 2025Observational
- Prevalence of Sarcopenia in Connective Tissue Disease Associated Interstitial Lung Diseases: A Single-Centre Study from India.Mediterranean journal of rheumatology · 2024Article
- Functional Measures in Non-COPD Chronic Respiratory Diseases: A Systematic Review.Journal of clinical medicine · 2024Review
- CT-based body composition analysis and pulmonary fat attenuation volume as biomarkers to predict overall survival in patients with non-specific interstitial pneumonia.European radiology experimental · 2024Article
- Sarcopenia in interstitial lung disease.European respiratory review : an official journal of the European Respiratory Society · 2024Review
- Association between body fat decrease during the first year after diagnosis and the prognosis of idiopathic pulmonary fibrosis: CT-based body composition analysis.Respiratory research · 2024Article
- Association of musculoskeletal involvement with lung function and mortality in patients with idiopathic pulmonary fibrosis.Respiratory research · 2024Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPatients with fibrotic interstitial lung disease (ILD) are frequently physically inactive and many ILD subtypes are characterized by risk factors for myopathy; however, the importance of body composition, muscle strength, and physical performance in this population is largely unknown.
methodsPatients were prospectively recruited from a specialized ILD clinic, baseline characteristics were collected from the clinical record, pulmonary function tests were performed per established protocols, and dyspnea was measured using the University of California San Diego Shortness of Breath Questionnaire. Dual-energy X-ray absorptiometry (DXA) was used to assess body composition; handgrip strength to determine muscle strength, and 4-m gait speed to measure physical performance.
resultsOne hundred and fifteen patients with fibrotic ILD including 40 patients with idiopathic pulmonary fibrosis were recruited. The mean age was 69+/- 10 years in men (62% of the cohort), and 66+/- 9 years in women, with mild and moderate reduction in FVC and DLCO, respectively, for both sexes. ILD severity (measured by FVC %-predicted, DLCO %-predicted, or the Composite Physiologic Index in separate models) significantly predicted muscle mass and percent body fat including with adjustment for age, sex, and weight. ILD severity was associated with grip strength and gait speed independent from body composition.
conclusionsILD severity has an important impact on body composition, particularly in men. Future studies are needed to confirm and further explore the possibility of additional pathways through which ILD directly impacts limb muscle function and physical performance.
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