ArticleBMC pregnancy and childbirth2019
Evaluation of risk factors' importance on adverse pregnancy and neonatal outcomes in women aged 40 years or older.
Article in BMC pregnancy and childbirth, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
- Effectiveness of telemedicine for pregnant women with gestational diabetes mellitus: an updated meta-analysis of 32 randomized controlled trials with trial sequential analysis.BMC pregnancy and childbirth · 2020Pooled it
- Fetomaternal Outcome Among Antenatal Attendees With Advanced Maternal Age: A Cohort Study.Cureus · 2025Article
- Perinatal outcomes and maternal health before and after single motherhood through assisted conception: A multiregistry study in Sweden.Acta obstetricia et gynecologica Scandinavica · 2025Article
- Neonatal Outcomes Among Infants of Mothers With Advanced Maternal Age: A National Cohort Study.Acta paediatrica (Oslo, Norway : 1992) · 2025Article
- Delaying Motherhood-An Increasingly Common but Risky Trend in High-Income Countries.American journal of human biology : the official journal of the Human Biology Council · 2025Article
- Pregnancy Outcomes Following Assisted Reproductive Technology in Advanced Maternal Age Primiparous Women: A Retrospective Cohort Study.International journal of women's health · 2025Article
- The Adverse Maternal Outcomes and Risk Factors of Adolescent Pregnancy: Evidence From a Retrospective Study in Astana, Kazakhstan.International journal of public health · 2025Article
- Uterine Aging and Reproduction: Dealing with a Puzzle Biologic Topic.International journal of molecular sciences · 2023Review
- The Correct Indication to Induce Labour in a Swiss Cantonal Hospital.Journal of clinical medicine · 2023Article
- Pregnancies in Elderly Mothers over 40 years: What to Expect from the Rising New Age High-Risk Cohort?Journal of obstetrics and gynaecology of India · 2023Article
- Perceived social support in solo women seeking treatment with donor gametes and in women in heterosexual couples seeking IVF-treatment with own gametes.Scientific reports · 2023Article
- Temporal trends and factors associated with preterm birth in Chile, 1992-2018.Salud colectiva · 2023Article
- Pregnancy-Specific Stress during the First Lockdown of the COVID-19 Pandemic: Assessing Face-to-Face versus Online Recruitment.International journal of environmental research and public health · 2022Article
- The influence of advanced age and obesity on pregnancy course and outcome in patients with diabetes mellitus.Przeglad menopauzalny = Menopause review · 2022Article
- Usefulness of second trimester left ventricular global longitudinal strain for predicting adverse maternal outcome in pregnant women aged 35 years or older.The international journal of cardiovascular imaging · 2022Article
- Maternal advanced age, single parenthood, and ART increase the risk of child morbidity up to five years of age.BMC pediatrics · 2022Article
- Adverse perinatal outcomes and its associated factors among adult and advanced maternal age pregnancy in Northwest Ethiopia.Scientific reports · 2021Article
- Neonatal Morbidity and Mortality in Advanced Aged Mothers-Maternal Age Is Not an Independent Risk Factor for Infants Born Very Preterm.Frontiers in pediatrics · 2021Article
- South Korean nurses' lived experiences supporting maternal postpartum bonding in the neonatal intensive care unit.International journal of qualitative studies on health and well-being · 2020Article
- Mothers who have given birth at an advanced age - health status before and after childbirth.Scientific reports · 2020Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWomen of advanced age (40 years or older) are generally, at risk for pregnancy and delivery related problems. In addition, there is limited knowledge on being of advanced age and having been given Assisted Reproductive Treatment (ART) and its association with negative obstetric outcomes. Therefore, data from the Swedish Medical Birth Register was used to investigate pregnancy and neonatal outcomes for women aged 40 or more who had given birth. The secondary aim was to compare the obstetric outcomes of women who had used ART and women who had not undergone ART while adjusting for marital status across the age groups.
methodWomen of advanced age who had given birth in Sweden during 2007-2012 formed the index group, n = 37,558; a reference group of women comprised 71,472 women under the age of 40. An additional subgroup of women aged 45 or older when giving birth was also formed, n = 2229. The obstetric and neonatal data for all the women was derived from national register data.
resultsWomen of advanced age were more often single, had undergone ART, and more often experienced adverse obstetric outcomes than did younger women. The neonate's health was also more often adversely affected expressed as being born with low birth weight and Small for Gestational Age (SGA), having lower Apgar scores, and having more health problems during the first week compared to the reference group.
conclusionsWomen who are approaching the upper limit of fecundity are at greater risk for having children who are preterm and SGA. The adverse effects of being preterm and SGA may have negative long-term effects, not only on the children but also on the mothers. This needs to be addressed more frequently in a clinical setting when advising women of all ages on pregnancy and ART treatment.
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