ArticleBMC microbiology2019
Epidemiology of paediatric gastrointestinal colonisation by extended spectrum cephalosporin-resistant Escherichia coli and Klebsiella pneumoniae isolates in north-west Cambodia.
Article in BMC microbiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Epidemiology of multidrug-resistant Klebsiella pneumoniae infection in clinical setting in South-Eastern Asia: a systematic review and meta-analysis.Antimicrobial resistance and infection control · 2023Pooled it
- Antibiotic and healthcare exposure impact on dynamics of third-generation cephalosporin-resistant Enterobacterales colonisation in Cambodian children: a six-month cohort study.Antimicrobial resistance and infection control · 2026Article
- Genomic Insights into Antimicrobial Resistance and Plasmid-Mediated Dissemination inAntibiotics (Basel, Switzerland) · 2026Article
- Prevalence and characterization of third-generation cephalosporin, carbapenem and colistin-resistant Enterobacterales isolated from clinical samples in Cambodia.New microbes and new infections · 2025Article
- Gut Microbiome and Intestinal Colonization with Multidrug-Resistant Strains of Enterobacterales: An Interplay Between Microbial Communities.Antibiotics (Basel, Switzerland) · 2025Review
- Faecal microbiota and cytokine profiles of rural Cambodian infants linked to diet and diarrhoeal episodes.NPJ biofilms and microbiomes · 2024Article
- The Rapid Emergence of HypervirulentTropical medicine and infectious disease · 2024Review
- Whole genome sequencing of multidrug resistant Enterobacterales identified in children and their household members within Siem Reap, Cambodia.JAC-antimicrobial resistance · 2023Article
- Community Fecal Carriage and Molecular Epidemiology of Extended-Spectrum β-Lactamase- and Carbapenemase-ProducingInfection and drug resistance · 2022Article
- Novel chromosomal insertions of ISEcp1-blaAntimicrobial resistance and infection control · 2021Article
- Epidemiology of Extended-Spectrum Beta-Lactamase and Carbapenemase-Producing Enterobacterales in the Greater Mekong Subregion: A Systematic-Review and Meta-Analysis of Risk Factors Associated With Extended-Spectrum Beta-Lactamase and Carbapenemase Isolation.Frontiers in microbiology · 2021Review
- Prevalence of MDR organism (MDRO) carriage in children and their household members in Siem Reap Province, Cambodia.JAC-antimicrobial resistance · 2020Article
- Beneficial Chromosomal Integration of the Genes for CTX-M Extended-Spectrum β-Lactamase inmSystems · 2020Article
- Detection of colonisation by extended-spectrum beta-lactamase or carbapenemase producing Enterobacterales from frozen stool specimens.BMC research notes · 2020Article
- Genomic surveillance for hypervirulence and multi-drug resistance in invasive Klebsiella pneumoniae from South and Southeast Asia.Genome medicine · 2020Article
- Molecular Characterization of Extended-Spectrum β-Lactamase-ProducingFrontiers in microbiology · 2020Article
Corrections and comments
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Authors and funding
15 authors.
Funding
Abstract
backgroundExtended-spectrum cephalosporin resistance (ESC-R) in Escherichia coli and Klebsiella pneumoniae is a healthcare threat; high gastrointestinal carriage rates are reported from South-east Asia. Colonisation prevalence data in Cambodia are lacking. The aim of this study was to determine gastrointestinal colonisation prevalence of ESC-resistant E. coli (ESC-R-EC) and K. pneumoniae (ESC-R-KP) in Cambodian children/adolescents and associated socio-demographic risk factors; and to characterise relevant resistance genes, their genetic contexts, and the genetic relatedness of ESC-R strains using whole genome sequencing (WGS).
resultsFaeces and questionnaire data were obtained from individuals < 16 years in north-western Cambodia, 2012. WGS of cultured ESC-R-EC/KP was performed (Illumina). Maximum likelihood phylogenies were used to characterise relatedness of isolates; ESC-R-associated resistance genes and their genetic contexts were identified from de novo assemblies using BLASTn and automated/manual annotation. 82/148 (55%) of children/adolescents were ESC-R-EC/KP colonised; 12/148 (8%) were co-colonised with both species. Independent risk factors for colonisation were hospitalisation (OR: 3.12, 95% CI [1.52-6.38]) and intestinal parasites (OR: 3.11 [1.29-7.51]); school attendance conferred decreased risk (OR: 0.44 [0.21-0.92]. ESC-R strains were diverse; the commonest ESC-R mechanisms were bla
conclusionsGastrointestinal ESC-R-EC/KP colonisation is widespread in Cambodian children/adolescents; hospital admission and intestinal parasites are independent risk factors. The genetic contexts of bla
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