ArticleEmerging microbes & infections2019
Prospective case-control analysis of the aetiologies of acute undifferentiated fever in Vietnam.
Article in Emerging microbes & infections, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Etiological spectrum of persistent fever in the tropics and predictors of ubiquitous infections: a prospective four-country study with pooled analysis.BMC medicine · 2022Trial
- Molecular-Based Detection of Vector-Borne Diseases in Shelter Dogs in Northern of Vietnam.Pathogens (Basel, Switzerland) · 2026Article
- The Comparative Study for Detection of Canine Vector-Borne Pathogens Between Companion and Stray Dogs in Bangkok and Vicinities, Thailand.Pathogens (Basel, Switzerland) · 2026Article
- Neglected rickettsial diseases in Southeast Asia: Twenty-five years of progress in surveillance, diagnostics, and clinical research.PLoS neglected tropical diseases · 2026Review
- Can Wastewater Surveillance Enhance Genomic Tracking of Climate-Driven Pathogens?Microorganisms · 2025Review
- Multi systemic compromise due to Bartonella henselae in a child.Revista do Instituto de Medicina Tropical de Sao Paulo · 2025Article
- Identification of Bacteria and Viruses Associated with Patients with Acute Febrile Illness in Khon Kaen Province, Thailand.Viruses · 2024Article
- From fever to action: diagnosis, treatment, and prevention of acute undifferentiated febrile illnesses.Pathogens and disease · 2024Review
- The detection of zoonotic microorganisms inFrontiers in veterinary science · 2024Article
- Aetiology of Acute Undifferentiated Fever Among Children Under the Age of Five in Vietnam: A Prospective Study.Journal of epidemiology and global health · 2023Article
- Identification of Vietnamese Flea Species and Their Associated Microorganisms Using Morphological, Molecular, and Protein Profiling.Microorganisms · 2023Article
- Mosquitoes and Mosquito-Borne Diseases in Vietnam.Insects · 2022Review
- Systematic Surveillance of Rickettsial Diseases in 27 Hospitals from 26 Provinces throughout Vietnam.Tropical medicine and infectious disease · 2022Article
- Simple clinical and laboratory predictors to improve empirical treatment strategies in areas of high scrub typhus and dengue endemicity, central Vietnam.PLoS neglected tropical diseases · 2022Article
- Opportunities and challenges to accurate diagnosis and management of acute febrile illness in adults and adolescents: A review.Acta tropica · 2022Review
- First Molecular Evidence of Pathogens in Fleas Collected from Dogs in Northern Vietnam.Pathogens (Basel, Switzerland) · 2021Article
- International Rickettsia Disease Surveillance: An Example of Cooperative Research to Increase Laboratory Capability and Capacity for Risk Assessment of Rickettsial Outbreaks Worldwide.Frontiers in medicine · 2021Review
- Molecular Detection of Microorganisms Associated with Small Mammals and Their Ectoparasites in Mali.The American journal of tropical medicine and hygiene · 2020Article
- Molecular detection of pathogens in ticks and fleas collected from companion dogs and cats in East and Southeast Asia.Parasites & vectors · 2020Article
- SARS-CoV-2: fear versus data.International journal of antimicrobial agents · 2020Article
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Authors and funding
9 authors.
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Abstract
Acute undifferentiated fever (AUF) is frequently observed in tropical settings, but diagnosing the cause of AUF is often a challenge for local physicians and the physicians treating returning travellers. We conducted a case-control study in central Vietnam in 2016. A total of 378 febrile adult patients (AUFs) with a fever for ≤21 days, no evidence of localized infection and negative screening tests for dengue and malaria, and 384 afebrile adult patients (Controls) were prospectively enrolled. Whole blood, plasma, eschar swab, throat swab and urine specimens were collected and analysed. Quantitative PCR and RT-PCR were used to test for 55 bacteria, viruses and their subtypes. Serological tests were also used to test for rickettsial agents. The most common aetiology was influenza virus (20.9% in AUFs vs. 0% in Controls), followed by rickettsial agents (mainly Orientia tsutsugamushi and Rickettsia typhi) (10.8% vs. 0.3%), dengue virus (7.7% vs. 0.5%), Leptospira (4.8% vs. 0.8%), adenovirus (4.8% vs. 1.0%), and enterovirus (2.1% vs. 0%) (p < .05). The real proportion of dengue in AUF cases was underestimated because patients with dengue-positive rapid diagnosis tests were excluded from the study. The emerging agent Rickettsia felis, which had not been previously observed in Vietnam, was detected in this study. In total, 216 patients (57.1%) were given causative diagnoses, comprising 143 (66.2%) monoinfections and 73 (33.8%) coinfections. The infections caused by these agents should be considered in clinical practice and further studies. Additionally, agents susceptible to doxycycline were detected in 15.6% of AUFs; thus, this drug should be included in the panel used to treat AUF patients.
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