Evidence map›Paper›PMID 30866779›Full record

ArticleEmerging microbes & infections2019

Multi-omics comparisons of p-aminosalicylic acid (PAS) resistance in folC mutated and un-mutated Mycobacterium tuberculosis strains.

Wenjing Wei, Huimin Yan, Jiao Zhao, Haicheng Li, Zhenyan Li, Huixin Guo, Xuezhi Wang, Ying Zhou, Xiaoli Zhang, Jincheng Zeng and 2 more

Open access · goldAbstract readComparative Study
In one paragraph

Article in Emerging microbes & infections, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 22 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 2 countries.

Wenjing Weia Center for Tuberculosis Control of Guangdong Province , Guangzhou , People's Republic of China.
Huimin Yanc Dongguan Key Laboratory of Medical Bioactive Molecular Development and Translational Research, Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics , Guangdong Medical University , Dongguan , People's Republic of China.
Jiao Zhaod Jinan University , Guangzhou , People's Republic of China.
Haicheng Lia Center for Tuberculosis Control of Guangdong Province , Guangzhou , People's Republic of China.
Zhenyan Lia Center for Tuberculosis Control of Guangdong Province , Guangzhou , People's Republic of China.
Huixin Guoa Center for Tuberculosis Control of Guangdong Province , Guangzhou , People's Republic of China.
Xuezhi Wanga Center for Tuberculosis Control of Guangdong Province , Guangzhou , People's Republic of China.
Ying Zhoue School of Stomatology and Medicine , Foshan University , Foshan , People's Republic of China.
Xiaoli Zhange School of Stomatology and Medicine , Foshan University , Foshan , People's Republic of China.
Jincheng Zengc Dongguan Key Laboratory of Medical Bioactive Molecular Development and Translational Research, Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics , Guangdong Medical University , Dongguan , People's Republic of China.
Tao Chena Center for Tuberculosis Control of Guangdong Province , Guangzhou , People's Republic of China.
Lin Zhoua Center for Tuberculosis Control of Guangdong Province , Guangzhou , People's Republic of China.
Center for Translational Molecular Medicine · NLCenter for Tuberculosis Control of Guangdong Province · CNFoshan University · CNKey Laboratory of Guangdong Province · CNGuangdong Medical College · CNJinan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

p-Aminosalicylic acid (PAS) is an important second-line antibiotic for treating multidrug-resistant tuberculosis (MDR-TB). Due to gastrointestinal disturbance and intolerance, its potent and efficacy in the treatment of extensively drug-resistant (XDR)-TB commonly are poor. Thus, it is important to reveal the mechanism of susceptibility and resistance of Mycobacterium tuberculosis (Mtb) to this drug. Herein, we screened and established PAS-resistant (PAS

Indexed as

Drug Resistance, BacterialMutationAminosalicylic AcidBacterial ProteinsComputational BiologyMetabolic Networks and PathwaysMetabolomicsMethionineMicrobial Sensitivity TestsMycobacterium tuberculosisPeptide SynthasesPhenylalanineProteomicsWhole Genome SequencingAminosalicylic AcidBacterial ProteinsMethioninePeptide SynthasesPhenylalaninefolCmulti-omicsMycobacterium tuberculosisP-Aminosalicylic acid

Identifiers

PMID30866779
PMCPMC6455211
OpenAlexW2911783621

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.