Evidence map›Paper›PMID 30866761›Full record

SynthesisEmerging microbes & infections2019

Chikungunya virus in Asia - Pacific: a systematic review.

B M C Randika Wimalasiri-Yapa, Liesel Stassen, Xiaodong Huang, Louise M Hafner, Wenbiao Hu, Gregor J Devine, Laith Yakob, Cassie C Jansen, Helen M Faddy, Elvina Viennet and 1 more

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Emerging microbes & infections, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Chikungunya seroprevalence in population-based studies: a systematic review and meta-analysis.Archives of public health = Archives belges de sante publique · 2023
    Pooled it
  3. Events preceding death among chikungunya virus infected patients: a systematic review.Revista da Sociedade Brasileira de Medicina Tropical · 2020
    Pooled it
  4. Article
  5. Review
  6. Review
  7. Review
  8. Five Hot Topics in Tropical Medicine: 2025.Infectious disease reports · 2026
    Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Observational
  14. Review
  15. Article
  16. Article
  17. Review
  18. Review
  19. Article
  20. Infectomics of Chikungunya Virus: Roles Played by Host Factors.The American journal of tropical medicine and hygiene · 2025
    Review

3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

B M C Randika Wimalasiri-Yapaa Institute of Health and Biomedical Innovation, School of Biomedical Sciences , Queensland University of Technology , Brisbane , QLD , Australia.
Liesel Stassena Institute of Health and Biomedical Innovation, School of Biomedical Sciences , Queensland University of Technology , Brisbane , QLD , Australia.
Xiaodong Huanga Institute of Health and Biomedical Innovation, School of Biomedical Sciences , Queensland University of Technology , Brisbane , QLD , Australia.
Louise M Hafnera Institute of Health and Biomedical Innovation, School of Biomedical Sciences , Queensland University of Technology , Brisbane , QLD , Australia.ORCID http://orcid.org/0000-0002-2117-4945
Wenbiao Huc Institute of Health and Biomedical Innovation, School of Public Health and Social Work , Queensland University of Technology , Brisbane , QLD , Australia.
Gregor J Devined Mosquito Control Laboratory , QIMR Berghofer Medical Research Institute , Brisbane , QLD , Australia.
Laith Yakobe Department of Disease Control, Faculty of Infectious & Tropical Diseases , The London School of Hygiene & Tropical Medicine , London , UK.
Cassie C Jansenf Communicable Diseases Branch, Department of Health , Queensland Government , Herston , QLD , Australia.
Helen M Faddyg Research and Development , Australian Red Cross Blood Service , Brisbane , QLD , Australia.
Elvina Viennetg Research and Development , Australian Red Cross Blood Service , Brisbane , QLD , Australia.
Francesca D Frentiua Institute of Health and Biomedical Innovation, School of Biomedical Sciences , Queensland University of Technology , Brisbane , QLD , Australia.ORCID http://orcid.org/0000-0001-8628-4216

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chikungunya virus (CHIKV) is a mosquito-borne pathogen that causes an acute febrile syndrome and severe, debilitating rheumatic disorders in humans that may persist for months. CHIKV's presence in Asia dates from at least 1954, but its epidemiological profile in the region remains poorly understood. We systematically reviewed CHIKV emergence, epidemiology, clinical features, atypical manifestations and distribution of virus genotypes, in 47 countries from South East Asia (SEA) and the Western Pacific Region (WPR) during the period 1954-2017. Following the Cochrane Collaboration guidelines, Pubmed and Scopus databases, surveillance reports available in the World Health Organisation (WHO) and government websites were systematically reviewed. Of the 3504 records identified, 461 were retained for data extraction. Although CHIKV has been circulating in Asia almost continuously since the 1950s, it has significantly expanded its geographic reach in the region from 2005 onwards. Most reports identified in the review originated from India. Although all ages and both sexes can be affected, younger children and the elderly are more prone to severe and occasionally fatal forms of the disease, with child fatalities recorded since 1963 from India. The most frequent clinical features identified were arthralgia, rash, fever and headache. Both the Asian and East-Central-South African (ECSA) genotypes circulate in SEA and WPR, with ECSA genotype now predominant. Our findings indicate a substantial but poorly documented burden of CHIKV infection in the Asia-Pacific region. An evidence-based consensus on typical clinical features of chikungunya could aid in enhanced diagnosis and improved surveillance of the disease.

Indexed as

Age DistributionAsia, SoutheasternChikungunya FeverChikungunya virusEvidence-Based MedicineFemaleGenotypeHumansMalePhylogeographyalphavirusArbovirusemerging virusmosquitoviral arthritis

Identifiers

PMID30866761
PMCPMC6455125

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.