Evidence map›Paper›PMID 30866608›Full record

ArticleTurkish journal of medical sciences2019

Down-regulation of circular RNA ITCH and circHIPK3 in gastric cancer tissues

Sara Ghasemi, Modjtaba Emadi-Baygi, Parvaneh Nikpour

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Turkish journal of medical sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 3 pooled it
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 3 syntheses or guidelines pooled it, 43 citations in OpenAlex.

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  12. Circular RNA circHIPK3 modulates prostate cancer progression via targeting miR-448/MTDH signaling.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Sara GhasemiORCID 0000-0001-5547-9352
Modjtaba Emadi-BaygiORCID 0000-0001-7492-6760
Parvaneh NikpourORCID 0000-0002-1784-6040

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background/aim: Gastric cancer (GC) is one of the major causes of cancer mortality worldwide. As a novel type of endogenous noncoding RNAs, circular RNAs (circRNAs) are formed by a covalent link between 5’ and 3’ ends. They are very stable and abundant in eukaryotes. As there were no reported studies on the expression profiles of circular RNA ITCH (cir-ITCH) and circHIPK3 in GC, in the current study, we aimed to delineate the expression profiles and clinicopathological relevance of these two circRNAs in GC tissues compared to their paired adjacent noncancerous tissues. Materials and methods: Quantitative real-time polymerase chain reaction was performed to evaluate cir_ITCH and circHIPK3 expression in 30 paired gastric cancer tissues. The clinicopathological relevance of these two circular RNAs’ expression levels with gastric cancer was further examined. Results: Our results showed that the expression of cir_ITCH and circHIPK3 were significantly downregulated in GC tumoral tissues compared with their paired adjacent nonneoplastic counterparts. Further analyses showed that cir_ITCH and circHIPK3 expression levels were related with numerous clinicopathological features of tumoral tissues. Conclusion: Cir_ITCH and circHIPK3 may have imperative roles in GC and serve in the future as potential prognostic biomarkers in GC.

Indexed as

Down-RegulationGene Expression Regulation, NeoplasticAgedCell Line, TumorFemaleGene Expression ProfilingHumansIntracellular Signaling Peptides and ProteinsMaleMiddle AgedProtein Serine-Threonine KinasesReal-Time Polymerase Chain ReactionRepressor ProteinsRNARNA, CircularSignal TransductionHIPK3 protein, humanIntracellular Signaling Peptides and ProteinsITCH protein, humanProtein Serine-Threonine KinasesRepressor ProteinsRNARNA, CircularUbiquitin-Protein LigasescircHIPK3circular RNAscir_ITCHGastric cancergene expression

Identifiers

PMID30866608
PMCPMC7018364
OpenAlexW2920837120

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.