Evidence map›Paper›PMID 30866536›Full record

ReviewMolecules (Basel, Switzerland)2019

Recent Advances in Aptamer Discovery and Applications.

Yang Zhang, Bo Shiun Lai, Mario Juhas

Abstract readReview
In one paragraph

Review in Molecules (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 229 papers.

0numbers the graph read from it
0cells of the map it votes in
229citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

229 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Advances in Aptamer Drug Delivery Systems for Treatment of Glioblastoma.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  6. Review
  7. Review
  8. Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Review
  17. Microfluidic Isolation of Aptamers for Intracellular Measurement of Radio-Responsive Proteins.Radiation (Multidisciplinary Digital Publishing Institute) · 2025
    Article
  18. Review
  19. Article
  20. Review

169 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Yang ZhangCollege of Science, Harbin Institute of Technology, Shenzhen 518055, China. zhangyang07@hit.edu.cn.ORCID 0000-0002-3503-5161
Bo Shiun LaiSchool of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA. boshiun@jhmi.edu.
Mario JuhasInstitute of Medical Microbiology, University of Zurich, Gloriastrasse 28/30, CH-8006 Zurich, Switzerland. mjuhas@imm.uzh.ch.

Funding

Natural Science Foundation of Shenzhen City JCYJ20170307150444573
6 · The paper itself

Abstract

Aptamers are short, single-stranded DNA, RNA, or synthetic XNA molecules that can be developed with high affinity and specificity to interact with any desired targets. They have been widely used in facilitating discoveries in basic research, ensuring food safety and monitoring the environment. Furthermore, aptamers play promising roles as clinical diagnostics and therapeutic agents. This review provides update on the recent advances in this rapidly progressing field of research with particular emphasis on generation of aptamers and their applications in biosensing, biotechnology and medicine. The limitations and future directions of aptamers in target specific delivery and real-time detection are also discussed.

Indexed as

AnimalsAptamers, NucleotideBiosensing TechniquesBiotechnologyEnvironmental MonitoringFood SafetyHumansMedicineSELEX Aptamer TechniqueAptamers, Nucleotideaptamerbiosensordiagnosticsnanorocketsystematic evolution of ligands by exponential enrichment (SELEX)therapeutics

Identifiers

PMID30866536
PMCPMC6429292

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.