Evidence map›Paper›PMID 30866531›Full record

ArticleBrain sciences2019

Empagliflozin Ameliorates Type 2 Diabetes-Induced Ultrastructural Remodeling of the Neurovascular Unit and Neuroglia in the Female

Melvin R Hayden, DeAna G Grant, Annayya R Aroor, Vincent G DeMarco

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05262257 (Evaluation and Intervention of Cognitive Function in Patients With Diabetes Mellitus.), which is not on this map. Cited by 53 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed, 3 pooled it
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05262257 early_phase1unknown statusstarted 2022, after this paper: background citation

Evaluation and Intervention of Cognitive Function in Patients With Diabetes Mellitus.

Ran2022Enrolled120Registered outcomes4Posted comparisons0ConditionsType2 DiabetesArmsdapagliflozin, Lifestyle Intervention, Metformin
PMID 29368156PMID 29626315PMID 31430566PMID 32848437PMID 32941881PMID 33187206PMID 34234493PMID 34291435PMID 27570337PMID 26969101PMID 25698435PMID 25344694other papers from this trial
Open the trial in the graph
3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 3 syntheses or guidelines pooled it, 93 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Melvin R HaydenDiabetes and Cardiovascular Center, School of Medicine, University of Missouri, Columbia, MO 65212, USA. mrh29pete@gmail.com.
DeAna G GrantElectron Microscopy Core Facility, University of Missouri, Columbia, MO 65212, USA. GrantDe@missouri.edu.
Annayya R AroorDiabetes and Cardiovascular Center, School of Medicine, University of Missouri, Columbia, MO 65212, USA. aroora@health.missouri.edu.ORCID 0000-0001-9203-4280
Vincent G DeMarcoDiabetes and Cardiovascular Center, School of Medicine, University of Missouri, Columbia, MO 65212, USA. demarcov@missouri.edu.
University of Missouri · USHarry S. Truman Memorial Veterans' Hospital · USUniversity of Missouri Health System · US

Funding

Excellence in Electron Microscopy issued by the University of Missouri Electron Microscopy Core and Office of Research no number
6 · The paper itself

Abstract

Type 2 diabetes is associated with diabetic cognopathy. Anti-hyperglycemic sodium glucose transporter 2 (SGLT2) inhibitors have shown promise in reducing cognitive impairment in mice with type 2 diabetes mellitus. We recently described marked ultrastructural (US) remodeling of the neurovascular unit (NVU) in type 2 diabetic

Indexed as

astrocyteendothelial cellmicrogliamitochondriamyelinneurogliaoligodendrocytepericytesodium glucose co-transporter 2 inhibitor (SGLT2i)white matter

Identifiers

PMID30866531
PMCPMC6468773
OpenAlexW2918545450

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.