Evidence map›Paper›PMID 30866433›Full record

ArticleInternational journal of molecular sciences2019

Histone Deacetylase Inhibitor, Trichostatin A, Synergistically Enhances Paclitaxel-Induced Cytotoxicity in Urothelial Carcinoma Cells by Suppressing the ERK Pathway.

Fu-Shun Hsu, June-Tai Wu, Jing-Yi Lin, Shao-Ping Yang, Kuan-Lin Kuo, Wei-Chou Lin, Chung-Sheng Shi, Po-Ming Chow, Shih-Ming Liao, Chun-I Pan and 3 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 25 citations in OpenAlex.

  1. The histone deacetylase family in health and disease.Signal transduction and targeted therapy · 2026
    Review
  2. Histone deacetylases and their inhibitors in kidney diseases.Molecular therapy : the journal of the American Society of Gene Therapy · 2025
    Review
  3. Article
  4. Article
  5. What nature has to offer: Opportunities for immuno-oncology.Journal of food and drug analysis · 2023
    Review
  6. Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. NIPSNAP protein family emerges as a sensor of mitochondrial health.BioEssays : news and reviews in molecular, cellular and developmental biology · 2021
    Review
  13. Article
  14. Article
  15. Article
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Fu-Shun HsuDepartment of Urology, New Taipei City Hospital, New Taipei City 112, Taiwan. fs_hsu@outlook.com.ORCID 0000-0002-4586-7308
June-Tai WuDepartment of Dermatology, National Taiwan University Hospital, Taipei 100, Taiwan. junetai.wu@gmail.com.
Jing-Yi LinDepartment of Dermatology, Chang Gung Memorial Hospital, Keelung 204, Taiwan. lindajylin@cgmh.org.tw.
Shao-Ping YangDepartment of Urology, New Taipei City Hospital, New Taipei City 112, Taiwan. emilyang719@gmail.com.
Kuan-Lin KuoDepartment of Urology, New Taipei City Hospital, New Taipei City 112, Taiwan. antibody0123@gmail.com.
Wei-Chou LinDepartment of Pathology, National Taiwan University Hospital, Taipei 100, Taiwan. weichou8@ms52.hinet.net.
Chung-Sheng ShiGraduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan. csshi@mail.cgu.edu.tw.ORCID 0000-0002-5548-7675
Po-Ming ChowDepartment of Urology, National Taiwan University Hospital, Taipei 100, Taiwan. meow1812@gmail.com.ORCID 0000-0002-3183-1830
Shih-Ming LiaoDepartment of Urology, New Taipei City Hospital, New Taipei City 112, Taiwan. sanguine444@gmail.com.
Chun-I PanDepartment of Urology, New Taipei City Hospital, New Taipei City 112, Taiwan. vickypan0686@gmail.com.
Jo-Yu HongDepartment of Urology, National Taiwan University Hospital, Taipei 100, Taiwan. yvonnehorng@gmail.com.
Hong-Chiang ChangDepartment of Urology, National Taiwan University Hospital, Taipei 100, Taiwan. changhong@ntu.edu.tw.
Kuo-How HuangGraduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei 106, Taiwan. khhuang123@ntu.edu.tw.ORCID 0000-0002-0989-0578
National Taiwan University Hospital · TWNational Taiwan University · TWTaipei City Hospital · TWChang Gung University · TW

Funding

National Taiwan University Hospital 103-S2349
6 · The paper itself

Abstract

Trichostatin A (TSA), an antifungal antibiotic derived from

Indexed as

AnimalsCarcinoma, Transitional CellCell Line, TumorCell ProliferationCell SurvivalDrug SynergismGene Expression Regulation, NeoplasticHistone Deacetylase InhibitorsHumansHydroxamic AcidsMAP Kinase Signaling SystemMicePaclitaxelTreatment OutcomeUrinary Bladder NeoplasmsXenograft Model Antitumor AssaysHistone Deacetylase InhibitorsHydroxamic AcidsPaclitaxeltrichostatin Achemotherapyhistone deacetylase inhibitorpaclitaxeltrichostatin Aurothelial carcinoma

Identifiers

PMID30866433
PMCPMC6429437
OpenAlexW2919939285

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.