ArticleKidney research and clinical practice2019
Risk of cancer in pre-dialysis chronic kidney disease: A nationwide population-based study with a matched control group.
Article in Kidney research and clinical practice, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Chronic kidney disease and risk of kidney or urothelial malignancy: systematic review and meta-analysis.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2024Pooled it
- Outpatient visit intervals in chronic kidney disease: adherence to Kidney Disease: Improving Global Outcomes recommendations and determinants of variation.Kidney research and clinical practice · 2026Article
- Unveiling the comorbidity hub: WT1 drives renal cancer progression in chronic kidney disease and confers sirolimus vulnerability.Experimental and therapeutic medicine · 2026Article
- Prognostic Value of the Level of Urine Dipstick Proteinuria in Gastric Cancer in the Korean Population.Cancers · 2025Article
- Association between chronic kidney disease and colorectal cancer: evidence from meta-analysis and Mendelian randomization.Discover oncology · 2025Article
- Incidence of cancer in people with CKD not requiring kidney replacement therapy: a systematic review and meta-analysis.Clinical kidney journal · 2025Article
- Real-World Insights From Türkiye: Biologic DMARDs Usage in Spondyloarthritis Patients With Chronic Kidney Disease.International journal of rheumatic diseases · 2025Observational
- Association of chronic kidney disease with acute clinical outcomes and hospitalization costs of cancer resection.PloS one · 2025Article
- Urgent considerations on renal immune-related adverse events in oncology practice.Frontiers in immunology · 2025Review
- The risk of solid organ tumors in patients with chronic kidney disease: A narrative review of literature.Heliyon · 2024Article
- Association of decreased estimated glomerular filtration rate with lung cancer risk in the Korean population.Epidemiology and health · 2024Article
- The Impact of Chronic Kidney Disease on the Mortality Rates of Patients with Urological Cancers-An Analysis of a Uro-Oncology Database from Eastern Europe.Journal of personalized medicine · 2023Article
- The 'other' big complication: how chronic kidney disease impacts on cancer risks and outcomes.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2023Review
- Chronic kidney diseases and the risk of colorectal cancer: A systematic review and meta-analysis.Arab journal of urology · 2023Review
- Anti-TNF treatment in ankylosing spondylitis patients with chronic kidney disease: Is it effective and safe?European journal of rheumatology · 2022Article
- Risk of malignancy in patients with chronic kidney disease.PloS one · 2022Article
- Chronic kidney disease in cancer patients, the analysis of a large oncology database from Eastern Europe.PloS one · 2022Observational
- Chronic Kidney Disease and Cancer: Inter-Relationships and Mechanisms.Frontiers in cell and developmental biology · 2022Review
- Clinical Significance of Acute Kidney Injury in Lung Cancer Patients.Cancer research and treatment · 2021Article
- Kidney function and cancer risk: An analysis using creatinine and cystatin C in a cohort study.EClinicalMedicine · 2021Article
Corrections and comments
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Authors and funding
13 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCancer risk and epidemiology in pre-dialysis chronic kidney disease (CKD) warrant further investigation in a large-scale cohort.
methodsWe performed a nationwide population-based study using the national health insurance database of Korea. We screened records from 18,936,885 individuals who received a national health examination ≥ 2 times from 2009 to 2016. Pre-dialysis CKD was identified based on serum creatinine and dipstick albuminuria results. Individuals with preexisting cancer history, renal replacement therapy, or transient CKD were excluded. A control group without evidence of kidney function impairment and matched for age, sex, low-income status, and smoking history was included. Risk of cancers, as identified in the claims database, was investigated using a multivariable Cox regression model including matched variables and other unmatched clinical characteristics as covariates.
resultsA total of 471,758 people with pre-dialysis CKD and the same number of matched controls were included. Urinary (adjusted hazard ratio [HR], 1.97; 95% confidence interval [95% CI], 1.82-2.13) and hematopoietic (adjusted HR, 1.53; 95% CI, 1.38-1.68) malignancy risk was increased in pre-dialysis CKD and all CKD stages. However, the risk of digestive cancer was lower in the pre-dialysis CKD group (adjusted HR, 0.89; 95% CI, 0.87-0.92). The risk of digestive, respiratory, thyroid, and prostate malignancy demonstrated a non-linear association with CKD stage, with stage 1 or stage 4/5 CKD without dialysis demonstrating relatively lower risk.
conclusionCancer risk varied in pre-dialysis CKD compared to controls, and the association between cancer risk and CKD stage varied depending on the cancer type.
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