ArticleEquine veterinary journal2019
Adipose tissue dysfunction in obese horses with equine metabolic syndrome.
Article in Equine veterinary journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Risk factors for strangulating lipoma obstruction and lipomata in horses.Equine veterinary journal · 2026Article
- The Role of Omega-3 Fatty Acids in Horses' Nutrition-A Review.Animals : an open access journal from MDPI · 2026Review
- Equine models in translational medicine: A comparative approach to human health.Animal models and experimental medicine · 2026Review
- Generalized steatitis in a miniature horse filly with laminitis and a positive outcome at 18-month follow-up.The Canadian veterinary journal = La revue veterinaire canadienne · 2025Article
- Forage Carbohydrate Profiles and Endocrine Morphometric Interactions in Traditionally Managed Horses from Romania.Life (Basel, Switzerland) · 2025Article
- Revitalizing equine metabolism: how SHBG improves mitochondrial function and reduces inflammation.BMC veterinary research · 2025Article
- Effect of Exercise Conditioning on Countering the Effects of Obesity and Insulin Resistance in Horses-A Review.Animals : an open access journal from MDPI · 2024Review
- Article
- Concentrations of Selected Adipocytokines in the Blood Plasma in Proximal Suspensory Desmopathy of Horses, with a Focus on Their Physical Activity-A Pilot Study.International journal of molecular sciences · 2023Article
- Sex Hormone-Binding Globulin (SHBG) Maintains Proper Equine Adipose-Derived Stromal Cells (ASCs)' Metabolic Functions and Negatively Regulates their Basal Adipogenic Potential.Stem cell reviews and reports · 2023Article
- Equine Metabolic Syndrome: A Complex Disease Influenced by Multifactorial Genetic Factors.Genes · 2023Review
- Impacts of Adiposity on Exercise Performance in Horses.Animals : an open access journal from MDPI · 2023Review
- Horse serum potentiates cellular viability and improves indomethacin-induced adipogenesis in equine subcutaneous adipose-derived stem cells (ASCs).International journal of veterinary science and medicine · 2023Article
- Sex hormone-binding globulin improves lipid metabolism and reduces inflammation in subcutaneous adipose tissue of metabolic syndrome-affected horses.Frontiers in molecular biosciences · 2023Article
- Bioactive Phytochemicals fromInternational journal of molecular sciences · 2022Article
- Comparison of Sources and Methods for the Isolation of Equine Adipose Tissue-Derived Stromal/Stem Cells and Preliminary Results on Their Reaction to Incubation with 5-Azacytidine.Animals : an open access journal from MDPI · 2022Article
- Article
- Age and Body Condition Influence the Post-Prandial Interleukin-1β Response to a High-Starch Meal in Horses.Animals : an open access journal from MDPI · 2021Article
- Article
- The cresty neck score is an independent predictor of insulin dysregulation in ponies.PloS one · 2019Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
backgroundObesity is a common feature of equine metabolic syndrome (EMS). In other species, obese adipose tissue shows pathological features such as adipocyte hypertrophy, fibrosis, inflammation and impaired insulin signalling all of which contribute to whole body insulin dysregulation. Such adipose tissue dysfunction has not been investigated in horses.
objectivesTo determine if obese horses with EMS have adipose tissue dysfunction characterised by adipocyte hypertrophy, fibrosis, inflammation and altered insulin signalling. STUDY
designCross-sectional post-mortem study.
methodsSamples of peri-renal (visceral) and retroperitoneal adipose tissue were obtained at post-mortem from healthy horses (n = 9) and horses with EMS (n = 6). Samples were analysed to determine average adipocyte size, fibrotic content and expression of inflammatory and insulin signalling genes.
resultsHorses with metabolic syndrome showed marked adipocyte hypertrophy and increased expression of adipokines (leptin) and inflammatory cytokines (TNFα, IL1β and CCL2) in both adipose tissue depots compared to healthy horses. There were no differences in fibrosis or expression of genes relating to insulin signalling between the groups. MAIN LIMITATIONS: Cases used in this study had advanced EMS and may represent the end stage of the condition; the design of the study is such that we were unable to relate the identified adipose tissue dysfunction to whole body insulin dysregulation.
conclusionsHorses with obesity and EMS have significant dysfunction of the peri-renal and retroperitoneal adipose tissue that may contribute to whole body insulin dysregulation.
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