ArticleCell reports2019
Interstitial Migration of CD8αβ T Cells in the Small Intestine Is Dynamic and Is Dictated by Environmental Cues.
Article in Cell reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 26 citations in OpenAlex.
- Article
- CD8 T cells mediate immunosurveillance for neoantigen+ epithelial stem cells in the colon.bioRxiv : the preprint server for biology · 2025Article
- Article
- Functional Diversity of Memory CD8 T Cells is Spatiotemporally Imprinted.bioRxiv : the preprint server for biology · 2024Article
- Quantitative analyses of T cell motion in tissue reveals factors driving T cell search in tissues.eLife · 2023Article
- Chronic antigen in solid tumors drives a distinct program of T cell residence.Science immunology · 2023Article
- Small intestine and colon tissue-resident memory CD8Immunity · 2023Article
- CD103 fate mapping reveals that intestinal CD103Science immunology · 2022Article
- Intestinal CD8European journal of immunology · 2022Review
- Cellular interactions in resident memory T cell establishment and function.Current opinion in immunology · 2022Review
- (Not) Home alone: Antigen presenting cell - T Cell communication in barrier tissues.Frontiers in immunology · 2022Review
- An Overview of Tissue-Resident Memory T Cells in the Intestine: From Physiological Functions to Pathological Mechanisms.Frontiers in immunology · 2022Review
- Decoding Tissue-Residency: Programming and Potential of Frontline Memory T Cells.Cold Spring Harbor perspectives in biology · 2021Review
- Dynamic Imaging of IEL-IEC Co-Cultures Allows for Quantification of CD103-Dependent T Cell Migration.International journal of molecular sciences · 2021Article
- Anti-viral protective capacity of tissue resident memory T cells.Current opinion in virology · 2021Review
- Human intestinal tissue-resident memory T cells comprise transcriptionally and functionally distinct subsets.Cell reports · 2021Article
- Divergence of Tissue-Memory T Cells: Distribution and Function-Based Classification.Cold Spring Harbor perspectives in biology · 2020Review
- Resident memory CD8 T cells persist for years in human small intestine.The Journal of experimental medicine · 2019Article
- PD-1 Dynamically Regulates Inflammation and Development of Brain-Resident Memory CD8 T Cells During Persistent Viral Encephalitis.Frontiers in immunology · 2019Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
Abstract
The migratory capacity of adaptive CD8αβ T cells dictates their ability to locate target cells and exert cytotoxicity, which is the basis of immune surveillance for the containment of microbes and disease. The small intestine (SI) is the largest mucosal surface and is a primary site of pathogen entrance. Using two-photon laser scanning microscopy, we found that motility of antigen (Ag)-specific CD8αβ T cells in the SI is dynamic and varies with the environmental milieu. Pathogen-specific CD8αβ T cell movement differed throughout infection, becoming locally confined at memory. Motility was not dependent on CD103 but was influenced by micro-anatomical locations within the SI and by inflammation. CD8 T cells responding to self-protein were initially affected by the presence of self-Ag, but this was altered after complete tolerance induction. These studies identify multiple factors that affect CD8αβ T cell movement in the intestinal mucosa and show the adaptability of CD8αβ T cell motility.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.