Evidence map›Paper›PMID 30865775›Full record

Trial reportPain medicine (Malden, Mass.)2020

The Effect of Low-Carbohydrate and Low-Fat Diets on Pain in Individuals with Knee Osteoarthritis.

Larissa J Strath, Catherine D Jones, Alan Philip George, Shannon L Lukens, Shannon A Morrison, Taraneh Soleymani, Julie L Locher, Barbara A Gower, Robert E Sorge

Registry-linked trialOpen access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Pain medicine (Malden, Mass.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04343716 (Investigating Racial Differences in Diet Benefits for Knee Osteoarthritis), which is not on this map. Cited by 44 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 6 pooled it
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04343716 nacompletednot on this map

Investigating Racial Differences in Diet Benefits for Knee Osteoarthritis

TypeinterventionalSponsorUniversity of Alabama at BirminghamRan2020 to 2023Enrolled19ConditionsKnee OsteoarthritisArmsLow-carbohydrate diet
3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 6 syntheses or guidelines pooled it, 89 citations in OpenAlex.

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  20. Gut microbiota-mediated pain sensitization: mechanisms and therapeutic implications.Frontiers in pain research (Lausanne, Switzerland) · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Larissa J StrathDepartment of Psychology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Catherine D JonesDepartment of Psychology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Alan Philip GeorgeDepartment of Psychology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Shannon L LukensDepartment of Psychology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Shannon A MorrisonSchool of Nursing, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Taraneh SoleymaniDepartment of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Julie L LocherDivision of Gerontology, Geriatrics and Palliative Care, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Barbara A GowerDepartment of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Robert E SorgeDepartment of Psychology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
University of Alabama at Birmingham · US

Funding

Why is the prevalence of obesity so high in U.S. Southern States? Regional predictors of BMI and obesity treatment response.P30DK056336 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BARBARA A GOWER · 2000 to 2026
$31.9M
University of Alabama at Birmingham's Diabetes Research CenterP30DK079626 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Kirk Michael Habegger · 2013 to 2026
$19.5M
Translational Nutrition and Aging Research Academic Career Leadership AwardK07AG043588 · NIA · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI LOCHER, JULIE L. · 2012 to 2016
$583k
NIA NIH HHS K07 AG043588NIDDK NIH HHS P30 DK056336NIDDK NIH HHS P30 DK079626
6 · The paper itself

Abstract

objectiveOsteoarthritis is the most prominent form of arthritis, affecting approximately 15% of the population in the United States. Knee osteoarthritis (KOA) has become one of the leading causes of disability in older adults. Besides knee replacement, there are no curative treatments for KOA, so persistent pain is commonly treated with opioids, acetaminophen, and nonsteroidal anti-inflammatory drugs. However, these drugs have many unpleasant side effects, so there is a need for alternative forms of pain management. We sought to test the efficacy of a dietary intervention to reduce KOA.

designA randomized controlled pilot study to test the efficacy of two dietary interventions. SUBJECTS: Adults 65-75 years of age with KOA.

methodsParticipants were asked to follow one of two dietary interventions (low-carbohydrate [LCD], low-fat [LFD]) or continue to eat as usual (control [CTRL]) over 12 weeks. Functional pain, self-reported pain, quality of life, and depression were assessed every three weeks. Serum from before and after the diet intervention was analyzed for oxidative stress.

resultsOver a period of 12 weeks, the LCD reduced pain intensity and unpleasantness in some functional pain tasks, as well as self-reported pain, compared with the LFD and CTRL. The LCD also significantly reduced oxidative stress and the adipokine leptin compared with the LFD and CTRL. Reduction in oxidative stress was related to reduced functional pain.

conclusionsWe present evidence suggesting that oxidative stress may be related to functional pain, and lowering it through our LCD intervention could provide relief from pain and be an opioid alternative.

Indexed as

AgedDiet, Carbohydrate-RestrictedDiet, Fat-RestrictedFemaleHumansMaleOsteoarthritis, KneeOxidative StressPainPain ManagementPilot ProjectsTreatment OutcomeDietInterventionKnee PainLeptinOsteoarthritisOxidative Stress

Identifiers

PMID30865775
PMCPMC7999621
OpenAlexW2922052453

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.