Evidence map›Paper›PMID 30865533›Full record

ArticleEndocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists2019

ONCOGENE PANEL SEQUENCING ANALYSIS IDENTIFIES CANDIDATE ACTIONABLE GENES IN ADVANCED WELL-DIFFERENTIATED GASTROENTEROPANCREATIC NEUROENDOCRINE TUMORS.

Amit Tirosh, J Keith Killian, Yuelin Jack Zhu, David Petersen, Jennifer Walling, Ronit Mor-Cohen, Vladimir Neychev, Holly Stevenson, Xavier M Keutgen, Dhaval Patel and 3 more

Registry-linked trialOpen access · greenAbstract read
In one paragraph

Article in Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02315625 (A Phase II Trial of Mutation-Targeted Therapy With Sunitinib or Everolimus in Patients With Advanced Low-or Intermediate Grade Neuroendocrine Tumors of the Gastrointestinal Tract and Pancreas With or Without Cytoreductive Surgery), which is not on this map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02315625 phase2terminatednot on this map

A Phase II Trial of Mutation-Targeted Therapy With Sunitinib or Everolimus in Patients With Advanced Low-or Intermediate Grade Neuroendocrine Tumors of the Gastrointestinal Tract and Pancreas With or Without Cytoreductive Surgery

TypeinterventionalSponsorNational Cancer Institute (NCI)Ran2015 to 2019Enrolled16ConditionsNeuroendocrine Tumors, Neuroendocrine Carcinoma, Neuroendocrine Neoplasms, Carcinoma, NeuroendocrineArmsSunitinib, Everolimus
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 8 institutions in 2 countries.

Amit Tirosh
J Keith Killian
Yuelin Jack Zhu
David Petersen
Jennifer Walling
Ronit Mor-Cohen
Vladimir Neychev
Holly Stevenson
Xavier M Keutgen
Dhaval Patel
Naris Nilubol
Paul Meltzer
Electron Kebebew
National Cancer Institute · USMedical College of Wisconsin · USRush University Medical Center · USSheba Medical Center · ILStanford University · USTel Aviv University · ILThe University of Texas at Austin · USUniversity of Central Florida · US

Funding

Molecular Profiling of Clinical SpecimensZICBC011040 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI EDELMAN, DANIEL · 2009 to 2020
$25.5M
Therapeutic targets and novel anticancer agents for endocrine cancersZIABC011286 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI NILUBOL, NARIS · 2010 to 2025
$16.6M
Intramural NIH HHS Z99 CA999999Intramural NIH HHS ZIA BC011286Intramural NIH HHS ZIC BC011040
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Intestinal NeoplasmsNeuroendocrine TumorsPancreatic NeoplasmsStomach NeoplasmsHumans

Identifiers

PMID30865533
PMCPMC8170837
OpenAlexW2921402584

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.