Evidence map›Paper›PMID 30865486›Full record

SynthesisCirculation2019

CXCL12 Derived From Endothelial Cells Promotes Atherosclerosis to Drive Coronary Artery Disease.

Yvonne Döring, Emiel P C van der Vorst, Johan Duchene, Yvonne Jansen, Selin Gencer, Kiril Bidzhekov, Dorothee Atzler, Donato Santovito, Daniel J Rader, Danish Saleheen and 1 more

Abstract readLetterMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Circulation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

61 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Arteriosclerosis, thrombosis, and vascular biology · 2026
    Article
  4. CD8Nature reviews. Cardiology · 2026
    Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article

1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yvonne DöringInstitute for Cardivascular Prevention, Ludwig-Maximillians University Munich, Germany (Y.D., E.V., J.D., Y.J., S.G., K.B., D.A., D.S., C.W.).
Emiel P C van der VorstInstitute for Cardivascular Prevention, Ludwig-Maximillians University Munich, Germany (Y.D., E.V., J.D., Y.J., S.G., K.B., D.A., D.S., C.W.).
Johan DucheneInstitute for Cardivascular Prevention, Ludwig-Maximillians University Munich, Germany (Y.D., E.V., J.D., Y.J., S.G., K.B., D.A., D.S., C.W.).
Yvonne JansenInstitute for Cardivascular Prevention, Ludwig-Maximillians University Munich, Germany (Y.D., E.V., J.D., Y.J., S.G., K.B., D.A., D.S., C.W.).
Selin GencerInstitute for Cardivascular Prevention, Ludwig-Maximillians University Munich, Germany (Y.D., E.V., J.D., Y.J., S.G., K.B., D.A., D.S., C.W.).
Kiril BidzhekovInstitute for Cardivascular Prevention, Ludwig-Maximillians University Munich, Germany (Y.D., E.V., J.D., Y.J., S.G., K.B., D.A., D.S., C.W.).
Dorothee AtzlerInstitute for Cardivascular Prevention, Ludwig-Maximillians University Munich, Germany (Y.D., E.V., J.D., Y.J., S.G., K.B., D.A., D.S., C.W.).
Donato SantovitoInstitute for Cardivascular Prevention, Ludwig-Maximillians University Munich, Germany (Y.D., E.V., J.D., Y.J., S.G., K.B., D.A., D.S., C.W.).
Daniel J RaderDivision of Translational Medicine and Human Genetics, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia (D.R., D.S.).
Danish SaleheenDivision of Translational Medicine and Human Genetics, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia (D.R., D.S.).
Christian WeberInstitute for Cardivascular Prevention, Ludwig-Maximillians University Munich, Germany (Y.D., E.V., J.D., Y.J., S.G., K.B., D.A., D.S., C.W.).

Funding

Molecular mechanisms linking the CXCL12 pathway to atherosclerosisR01HL122843 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI RADER, DANIEL JAMES, SALEHEEN, DANISH · 2015 to 2018
$2.9M
NHLBI NIH HHS R01 HL122843
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Plaque, AtheroscleroticAnimalsChemokine CXCL12Coronary Artery DiseaseDisease Models, AnimalDisease ProgressionEndothelial CellsGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansMice, Knockout, ApoEPhenotypePolymorphism, Single NucleotideRisk FactorsChemokine CXCL12CXCL12 protein, humanCxcl12 protein, mouseatherosclerosischemokinescoronary artery diseasegenome-wide association studiesinflammation

Identifiers

PMID30865486
PMCPMC6417827

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.