ArticleMolecular biology and evolution2019
The Genome of Drosophila innubila Reveals Lineage-Specific Patterns of Selection in Immune Genes.
Article in Molecular biology and evolution, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 50 citations in OpenAlex.
- Draft hybrid assembly and annotation of the Drosophila palustris and Drosophila subpalustris genomes.G3 (Bethesda, Md.) · 2026Article
- Convergence and conflict among telomere-specialized transposons across 60 million years of Drosophilid evolution.Genome research · 2026Article
- Causes and consequences of sex-chromosome turnovers in Diptera.Evolution letters · 2026Article
- Predictors of Protein Evolution in the drosophilid Immune System.Genome biology and evolution · 2026Article
- Genetic variation in recalcitrant repetitive regions of theGenome research · 2025Article
- Genomic Diversity Illuminates the Environmental Adaptation of Drosophila suzukii.Genome biology and evolution · 2024Article
- Copy number variation and elevated genetic diversity at immune trait loci in Atlantic and Pacific herring.BMC genomics · 2024Article
- The genome sequence of the drosophilid fruit fly,Wellcome open research · 2024Article
- Unistrand piRNA clusters are an evolutionarily conserved mechanism to suppress endogenous retroviruses across the Drosophila genus.Nature communications · 2023Article
- Adaptive Evolution of the OAS Gene Family Provides New Insights into the Antiviral Ability of Laurasiatherian Mammals.Animals : an open access journal from MDPI · 2023Article
- Complex patterns shape immune genes diversity during invasion of common raccoon in Europe - Selection in action despite genetic drift.Evolutionary applications · 2023Article
- Population-Genomic Analysis Identifies a Low Rate of Global Adaptive Fixation in the Proteins of the Cyclical Parthenogen Daphnia magna.Molecular biology and evolution · 2022Article
- Migrators within migrators: exploring transposable element dynamics in the monarch butterfly, Danaus plexippus.Mobile DNA · 2022Article
- Positive Selection and Horizontal Gene Transfer in the Genome of a Male-Killing Wolbachia.Molecular biology and evolution · 2022Article
- The promise and deceit of genomic selection component analyses.Proceedings. Biological sciences · 2021Article
- The Drosophila Baramicin polypeptide gene protects against fungal infection.PLoS pathogens · 2021Article
- Rapid divergence of the male reproductive proteins in the Drosophila dunni group and implications for postmating incompatibilities between species.G3 (Bethesda, Md.) · 2021Article
- Adaptation, ancestral variation and gene flow in a 'Sky Island' Drosophila species.Molecular ecology · 2021Article
- Divergent evolution and purifying selection of the Type 2 diabetes gene sequences in Drosophila: a phylogenomic study.Genetica · 2020Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Pathogenic microbes can exert extraordinary evolutionary pressure on their hosts. They can spread rapidly and sicken or even kill their host to promote their own proliferation. Because of this strong selective pressure, immune genes are some of the fastest evolving genes across metazoans, as highlighted in mammals and insects. Drosophila melanogaster serves as a powerful model for studying host/pathogen evolution. While Drosophila melanogaster are frequently exposed to various pathogens, little is known about D. melanogaster's ecology, or if they are representative of other Drosophila species in terms of pathogen pressure. Here, we characterize the genome of Drosophila innubila, a mushroom-feeding species highly diverged from D. melanogaster and investigate the evolution of the immune system. We find substantial differences in the rates of evolution of immune pathways between D. innubila and D. melanogaster. Contrasting what was previously found for D. melanogaster, we find little evidence of rapid evolution of the antiviral RNAi genes and high rates of evolution in the Toll pathway. This suggests that, while immune genes tend to be rapidly evolving in most species, the specific genes that are fastest evolving may depend either on the pathogens faced by the host and/or divergence in the basic architecture of the host's immune system.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.