ArticleJournal of neurophysiology2019
Adapting the flow of time with dopamine.
Article in Journal of neurophysiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Effort, timing and choice: a refined rodent effort choice task with excellent sensitivity to dopamine modulators.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Dopaminergic processes predict temporal distortions in event memory.Nature communications · 2026Article
- Midbrain Dopamine Warps Subjective Time via Threshold Setting But Not Clock Speed.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Decreased Ventral Tegmental Area CB1R Signaling Reduces Sign Tracking and Shifts Cue-Outcome Dynamics in Rat Nucleus Accumbens.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- The neural bases for timing of durations.Nature reviews. Neuroscience · 2022Review
- The temporal context in bayesian models of interval timing: Recent advances and future directions.Behavioral neuroscience · 2022Article
- Dopamine mediates the bidirectional update of interval timing.Behavioral neuroscience · 2022Article
- A proxy measure of striatal dopamine predicts individual differences in temporal precision.Psychonomic bulletin & review · 2022Article
- Performance-gated deliberation: A context-adapted strategy in which urgency is opportunity cost.PLoS computational biology · 2022Article
- Revealing human sensitivity to a latent temporal structure of changes.Frontiers in behavioral neuroscience · 2022Article
- Review: Subjective Time Perception, Dopamine Signaling, and Parkinsonian Slowness.Frontiers in neurology · 2022Review
- Article
- Dopamine and the interdependency of time perception and reward.Neuroscience and biobehavioral reviews · 2021Review
- Awareness of errors and feedback in human time estimation.Learning & memory (Cold Spring Harbor, N.Y.) · 2021Article
- Rational inattention and tonic dopamine.PLoS computational biology · 2021Article
- Prediction errors bidirectionally bias time perception.Nature neuroscience · 2020Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
The modulation of interval timing by dopamine (DA) has been well established over decades of research. The nature of this modulation, however, has remained controversial: Although the pharmacological evidence has largely suggested that time intervals are overestimated with higher DA levels, more recent optogenetic work has shown the opposite effect. In addition, a large body of work has asserted DA's role as a "reward prediction error" (RPE), or a teaching signal that allows the basal ganglia to learn to predict future rewards in reinforcement learning tasks. Whether these two seemingly disparate accounts of DA may be related has remained an open question. By taking a reinforcement learning-based approach to interval timing, we show here that the RPE interpretation of DA naturally extends to its role as a modulator of timekeeping and furthermore that this view reconciles the seemingly conflicting observations. We derive a biologically plausible, DA-dependent plasticity rule that can modulate the rate of timekeeping in either direction and whose effect depends on the timing of the DA signal itself. This bidirectional update rule can account for the results from pharmacology and optogenetics as well as the behavioral effects of reward rate on interval timing and the temporal selectivity of striatal neurons. Hence, by adopting a single RPE interpretation of DA, our results take a step toward unifying computational theories of reinforcement learning and interval timing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.