Evidence map›Paper›PMID 30864838›Full record

ArticleAmerican journal of physiology. Renal physiology2019

Prompt apoptotic response to high glucose in SGLT-expressing renal cells.

Linnéa M Nilsson, Liang Zhang, Alexander Bondar, Daniel Svensson, Annika Wernerson, Hjalmar Brismar, Lena Scott, Anita Aperia

Open access · hybridAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Renal physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Review
  6. Article
  7. Review
  8. Molecular Mechanisms of SGLT2 Inhibitor on Cardiorenal Protection.International journal of molecular sciences · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Linnéa M NilssonScience for Life Laboratory, Department of Applied Physics, Royal Institute of Technology, Solna, Sweden.
Liang ZhangScience for Life Laboratory, Department of Women's and Children's Health, Karolinska Institutet, Solna, Sweden.
Alexander BondarInstitute of Chemical Biology and Fundamental Medicine, Novosibirisk, Russia.
Daniel SvenssonScience for Life Laboratory, Department of Women's and Children's Health, Karolinska Institutet, Solna, Sweden.
Annika WernersonDivision of Renal Medicine, Department of Clinical Science, Intervention and Technology, Karolinska Institutet , Stockholm , Sweden.
Hjalmar BrismarScience for Life Laboratory, Department of Applied Physics, Royal Institute of Technology, Solna, Sweden.
Lena ScottScience for Life Laboratory, Department of Women's and Children's Health, Karolinska Institutet, Solna, Sweden.
Anita AperiaScience for Life Laboratory, Department of Women's and Children's Health, Karolinska Institutet, Solna, Sweden.
Science for Life Laboratory · SEInstitute of Chemical Biology and Fundamental Medicine · RUKarolinska Institutet · SEKTH Royal Institute of Technology · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

It is generally believed that cells that are unable to downregulate glucose transport are particularly vulnerable to hyperglycemia. Yet, little is known about the relation between expression of glucose transporters and acute toxic effects of high glucose exposure. In the present ex vivo study of rat renal cells, we compared the apoptotic response to a moderate increase in glucose concentration. We studied cell types that commonly are targeted in diabetic kidney disease (DKD): proximal tubule cells, which express Na

Indexed as

AnimalsApoptosisCells, CulturedDiabetic NephropathiesEpithelial CellsGlucoseInsulinKidney Tubules, ProximalMaleMesangial CellsOuabainPodocytesRats, Sprague-DawleySignal TransductionSodium-Glucose Transporter 1Sodium-Glucose Transporter 2GlucoseInsulinOuabainSlc5a1 protein, ratSlc5a2 protein, ratSodium-Glucose Transporter 1Sodium-Glucose Transporter 2apoptosishyperglycemiapodocytesproximal tubular cellssodium-dependent glucose transporter

Identifiers

PMID30864838
PMCPMC6580252
OpenAlexW2920951643

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.