ArticleArchives of endocrinology and metabolism2019
Serum irisin and apelin levels and markers of atherosclerosis in patients with subclinical hypothyroidism.
Article in Archives of endocrinology and metabolism, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.
- Circulating Irisin Level and Thyroid Dysfunction: A Systematic Review and Meta-Analysis.BioMed research international · 2020Pooled it
- Cardiometabolic Outcomes and Levothyroxine Treatment Effects in Subclinical Hypothyroidism: A Systematic Review.Cureus · 2026Review
- The adipomyokine paradox and sex-specific metabolic divergence in subclinical hypothyroidism: a systematic review and meta-analysis.Cardiovascular diabetology. Endocrinology reports · 2026Review
- Thyroid function, autoimmunity, thyroid volume, and metabolic profile in people with Hashimoto thyroiditis.BMC endocrine disorders · 2024Article
- The Relationship between Subclinical Hypothyroidism and Carotid Intima-Media Thickness as a Potential Marker of Cardiovascular Risk: A Systematic Review and a Meta-Analysis.Journal of cardiovascular development and disease · 2024Review
- Correlation of serum apelin level with carotid intima-media thickness and insulin resistance in a sample of Egyptian patients with type 2 diabetes mellitus.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2022Article
- Secondary hormonal alterations in short-term severe hypothyroidism; in the focus: Apelin and copeptin.Frontiers in endocrinology · 2022Observational
- Thyroid hormones modulate irisin concentrations in patients with recently onset hypothyroidism following total thyroidectomy.Journal of endocrinological investigation · 2021Article
- The Potential Role of Irisin in Vascular Function and Atherosclerosis: A Review.International journal of molecular sciences · 2020Review
- The role of thyroid hormone in metabolism and metabolic syndrome.Therapeutic advances in endocrinology and metabolism · 2020Review
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveIn this study, we aimed to evaluate serum irisin and apelin levels in patients with subclinical hypothyroidism (SCH) when they were subclinical hypothyroid and become euthyroid after levothyroxine therapy and association of these adipokines with markers of atherosclerosis such as serum homocysteine levels and carotid intima-media thickness (IMT). SUBJECTS AND
methodsThe study included 160 patients with newly diagnosed subclinical hypothyroidism due to Hashimoto's thyroiditis and 86 euthyroid healty subjects. Serum glucose and lipid profile, insulin, HOMA, TSH, free T3, free T4, anti-thyroperoxidase and anti-thyroglobulin antibodies, homocysteine, apelin and irisin levels were measured in all study subjects. Thyroid and carotid ultrasound examinations were performed. The subclinical hypothyroid group was reevaluated after 12-weeks of levothyroxine therapy when they became euthyroid.
resultsClinical characteristics of the patient and control group were similar. Glucose, insulin and HOMA levels, lipid parameters and free T3 were similar between the two groups.. Serum homocystein was higher and apelin was lower in patients with SCH, but irisin levels were similar between the two groups. While thyroid volume was lower, carotid IMT was significantly greater in patients with SCH (pCarotidIMT:0,01). After 12-weeks of levothyroxine therapy, all the studied parameters remained unchanged except, serum freeT4, TSH, homocystein and apelin. While homocystein decreased (p: 0,001), apelin increased significantly (p = 0,049). In multivariate analysis, low apelin levels significantly contributed to carotid IMT (p = 0,041).
conclusionsApelin-APJ system may play a role in vascular and cardiac dysfunction in patients with SCH and treatment of this condition may improve the risk of cardiovascular disease.
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