ReviewCurrent aging science2019
Brain Ageing, Cognition and Diet: A Review of the Emerging Roles of Food-Based Nootropics in Mitigating Age-related Memory Decline.
Review in Current aging science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 60 citations in OpenAlex.
- Aging and Herbal Interventions: Mechanistic Insights and Therapeutic Potential.Journal of cosmetic dermatology · 2025Pooled it
- Influence of Cooking Methods on Flavor Parameters and Sensory Quality of Tibetan Sheep Meat Examined Using an Electronic Nose, an Electronic Tongue, GC-IMS, and GC-MS.Foods (Basel, Switzerland) · 2025Article
- Effects of L-carnitine on aging-related learning changes and glutamate-mediated molecular mechanisms.Experimental brain research · 2025Article
- Nootropic foods in neurodegenerative diseases: mechanisms, challenges, and future.Translational neurodegeneration · 2025Review
- Kiperin Mind Focus supplement mitigates chronic stress-induced neuroinflammation and molecular dysregulation and improves stress-related affective and exploratory behaviors in rats.Frontiers in integrative neuroscience · 2025Article
- Unveiling the role of erinacines in the neuroprotective effects ofFrontiers in pharmacology · 2025Review
- Assessment of retention and attenuation of motor-learning memory by repeated rotor-rod analyses.Scientific reports · 2024Article
- Comprehensive Review of Nutraceuticals against Cognitive Decline Associated with Alzheimer's Disease.ACS omega · 2023Review
- Mechanism of Molecular Activity of Yolkin-a Polypeptide Complex Derived from Hen Egg Yolk-in PC12 Cells and Immortalized Hippocampal Precursor Cells H19-7.Molecular neurobiology · 2023Article
- Longitudinal Examination of Body Mass Index and Cognitive Function in Older Adults: The HELIAD Study.Nutrients · 2023Article
- Long-Term Supplementation ofNutrients · 2023Article
- Impact of AmaTea® Max on physiological measures and gaming performance in active gamers: A placebo-controlled, double-blind, randomized study.Journal of clinical and translational research · 2022Article
- Edible Bird's Nest as a Potential Cognitive Enhancer.Frontiers in neurology · 2022Review
- Acute Effect of a Dietary Multi-Ingredient Nootropic as a Cognitive Enhancer in Young Healthy Adults: A Randomized, Triple-Blinded, Placebo-Controlled, Crossover Trial.Frontiers in nutrition · 2022Article
- Leucine mediates cognitive dysfunction in early life stress-induced mental disorders by activating autophagy.Frontiers in cellular neuroscience · 2022Article
- Accommodating Serial Correlation and Sequential Design Elements in Personalized Studies and Aggregated Personalized Studies.Harvard data science review · 2022Article
- Adults who microdose psychedelics report health related motivations and lower levels of anxiety and depression compared to non-microdosers.Scientific reports · 2021Article
- Herbal drugs and natural bioactive products as potential therapeutics: A review on pro-cognitives and brain boosters perspectives.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2021Review
- The Aging Brain Cohort (ABC) repository: The University of South Carolina's multimodal lifespan database for studying the relationship between the brain, cognition, genetics and behavior in healthy aging.Neuroimage. Reports · 2021Article
- The Psychonauts' World of Cognitive Enhancers.Frontiers in psychiatry · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAge-related cognitive decline has been suggested to result from an increase in the brain neuron loss, which is attributable to continued derangement of the brain's oxidant/ antioxidant balance. Increased oxidative stress and a concomitant decrease in the brain's antioxidant defense system have been associated with functional senescence and organismal ageing. However, nature has configured certain foods to be rich sources of nootropic agents, with research showing that increased consumption of such foods or food ingredients may be protective against ageing-related memory decline. This knowledge is becoming increasingly valuable in an era when the boundary that separates food from medicine is becoming blurred. In this review, we examine extant literature dealing with the impact of ageing on brain structure and function, with an emphasis on the roles of oxidative stress. Secondly, we review the benefits of food-based antioxidants with nootropic effects and/or food-based nootropic agents in mitigating memory decline; with a view to improving our understanding of likely mechanisms. We also highlight some of the limitations to the use of food-based nootropics and suggest ways in which they can be better employed in the clinical management of age-related cognitive decline.
conclusionWhile it is known that the human brain endures diverse insults in the process of ageing, food-based nootropics are likely to go a long way in mitigating the impacts of these insults. Further research is needed before we reach a point where food-based nootropics are routinely prescribed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.