Evidence map›Paper›PMID 30864344›Full record

ArticlePacific Symposium on Biocomputing. Pacific Symposium on Biocomputing2019

Merging heterogeneous clinical data to enable knowledge discovery.

Martin G Seneviratne, Michael G Kahn, Tina Hernandez-Boussard

Abstract read
In one paragraph

Article in Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Review of Clinical Research Informatics.Yearbook of medical informatics · 2020
    Review
  8. Article
  9. Exploring the dark genome: implications for precision medicine.Mammalian genome : official journal of the International Mammalian Genome Society · 2019
    Review
  10. Exploring the Hazards of Scaling Up Clinical Data Analyses: A Drug Side Effect Discovery Case Report.AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Martin G SeneviratneDepartment of Biomedical Data Science, Stanford University, 1265 Welch Rd, Stanford, CA 94305, United States, martsen@stanford.edu.
Michael G Kahn
Tina Hernandez-Boussard

Funding

NIH Prior Approval Process ProfessionalUL1TR002535 · NCATS · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2018 to 2022
$51.1M
Utilizing Electronic Health Records to Measure and Improve Prostate Cancer CareR01CA183962 · NCI · STANFORD UNIVERSITY · PI HERNANDEZ-BOUSSARD, TINA · 2015 to 2019
$3.1M
NCATS NIH HHS UL1 TR002535NCI NIH HHS R01 CA183962
6 · The paper itself

Abstract

The vision of precision medicine relies on the integration of large-scale clinical, molecular and environmental datasets. Data integration may be thought of along two axes: data fusion across institutions, and data fusion across modalities. Cross-institutional data sharing that maintains semantic integrity hinges on the adoption of data standards and a push toward ontology-driven integration. The goal should be the creation of query-able data repositories spanning primary and tertiary care providers, disease registries, research organizations etc. to produce rich longitudinal datasets. Cross-modality sharing involves the integration of multiple data streams, from structured EHR data (diagnosis codes, laboratory tests) to genomics, imaging, monitors and patient-generated data including wearable devices. This integration presents unique technical, semantic, and ethical challenges; however recent work suggests that multi-modal clinical data can significantly improve the performance of phenotyping and prediction algorithms, powering knowledge discovery at the patient- and population-level.

Indexed as

Big DataComputational BiologyHumansInformation DisseminationKnowledge DiscoveryPrecision MedicineUnited States

Identifiers

PMID30864344
PMCPMC6447393

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.