ArticleHuman brain mapping2019
Altered ability to access a clinically relevant control network in patients remitted from major depressive disorder.
Article in Human brain mapping, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
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Who cites it
55 citing papers in PubMed.
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- Investigating the influence of maternal prenatal BMI and perinatal depressive symptoms on neonatal brain network dynamics.Pediatric research · 2026Article
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- The turbulent brain: Modeling vortex interactions for understanding human cognition.Network neuroscience (Cambridge, Mass.) · 2026Article
- Lysergic acid diethylamide-derived excitatory/inhibitory ratio change enhances global synchrony in functional brain dynamics.PLoS computational biology · 2025Article
- Creativity in Music: The Brain Dynamics of Jazz Improvisation.Annals of the New York Academy of Sciences · 2025Article
- Review of Dynamic Resting-State Methods in Neuroimaging: Applications to Depression and Rumination.Human brain mapping · 2025Review
- Abnormal resting-state brain network dynamics in toddlers with autism spectrum disorder.European child & adolescent psychiatry · 2025Article
- Bridging local and global dynamics: a biologically grounded model for cooperative and competitive interactions in the brain.bioRxiv : the preprint server for biology · 2025Article
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- Whole-brain turbulent dynamics predict responsiveness to pharmacological treatment in major depressive disorder.Molecular psychiatry · 2025Article
- Understanding Altered Dynamics in Cocaine Use Disorder Through State Transitions Mediated by Artificial Perturbations.Brain sciences · 2025Article
- Atypical attentional network dynamics in adolescent depression during emotional movie viewing.Social cognitive and affective neuroscience · 2025Article
- Differences in dynamic functional connectivity between musicians and non-musicians during naturalistic music listening.Frontiers in neuroscience · 2025Article
- Differences in dynamic functional connectivity between naturalistic music listening and rest in preadolescents.Frontiers in human neuroscience · 2025Article
- Time-resolved instantaneous functional loci estimation (TRIFLE): Estimating time-varying allocation of spatially overlapping sources in functional magnetic resonance imaging.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Abnormal Dynamic Reconfiguration of Multilayer Temporal Networks in Patients with Bipolar Disorder.Brain sciences · 2024Article
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10 authors.
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Abstract
Neurobiological models to explain vulnerability of major depressive disorder (MDD) are scarce and previous functional magnetic resonance imaging studies mostly examined "static" functional connectivity (FC). Knowing that FC constantly evolves over time, it becomes important to assess how FC dynamically differs in remitted-MDD patients vulnerable for new depressive episodes. Using a recently developed method to examine dynamic FC, we characterized re-emerging FC states during rest in 51 antidepressant-free MDD patients at high risk of recurrence (≥2 previous episodes), and 35 healthy controls. We examined differences in occurrence, duration, and switching profiles of FC states after neutral and sad mood induction. Remitted MDD patients showed a decreased probability of an FC state (p < 0.005) consisting of an extensive network connecting frontal areas-important for cognitive control-with default mode network, striatum, and salience areas, involved in emotional and self-referential processing. Even when this FC state was observed in patients, it lasted shorter (p < 0.005) and was less likely to switch to a smaller prefrontal-striatum network (p < 0.005). Differences between patients and controls decreased after sad mood induction. Further, the duration of this FC state increased in remitted patients after sad mood induction but not in controls (p < 0.05). Our findings suggest reduced ability of remitted-MDD patients, in neutral mood, to access a clinically relevant control network involved in the interplay between externally and internally oriented attention. When recovering from sad mood, remitted recurrent MDD appears to employ a compensatory mechanism to access this FC state. This study provides a novel neurobiological profile of MDD vulnerability.
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