ArticleClinical oral investigations2019
Histological evaluation of hard tissue formation after direct pulp capping with a fast-setting mineral trioxide aggregate (RetroMTA) in humans.
Article in Clinical oral investigations, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03631511 (Histological Evaluation of Direct Pulp Capping on Human Pulp Tissue Using a RetroMTA), which is not on this map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Histological Evaluation of Direct Pulp Capping on Human Pulp Tissue Using a RetroMTA
Who cites it
21 citing papers in PubMed, 49 citations in OpenAlex.
- Shear Bond Strength of TheraCal PT and Calcium Silicate-Based Cement to a Flowable Composite Resin According to Bonding Strategy.Journal of functional biomaterials · 2026Article
- Effects of adhesive application timing on the push-out bond strength of four calcium silicate-based cements: a comparative study in vitro.BMC oral health · 2026Article
- Effectiveness of mineral trioxide aggregate and its modifications in inducing dentin bridge formation during pulp capping: A systematic review.Journal of conservative dentistry and endodontics · 2025Review
- Guidance for evaluating biomaterials' properties and biological potential for dental pulp tissue engineering and regeneration research.Dental materials : official publication of the Academy of Dental Materials · 2025Review
- Effect of nanoparticulate CaCOScientific reports · 2025Article
- Different pulp capping agents and their effect on pulp inflammatory response: A narrative review.The Saudi dental journal · 2024Review
- Impaired Tertiary Dentin Secretion after Shallow Injury inInternational journal of molecular sciences · 2024Article
- An animal study on the effectiveness of platelet-rich plasma as a direct pulp capping agent.Scientific reports · 2024Article
- Epigenetic therapeutics in dental pulp treatment: Hopes, challenges and concerns for the development of next-generation biomaterials.Bioactive materials · 2023Article
- Cell-scaffold interactions in tissue engineering for oral and craniofacial reconstruction.Bioactive materials · 2023Article
- Biomineralization-inspired mineralized hydrogel promotes the repair and regeneration of dentin/bone hard tissue.NPJ Regenerative medicine · 2023Article
- Direct pulp capping with autologous bone marrow derived stem cells in dogs.Veterinary research forum : an international quarterly journal · 2022Article
- The Influence of New Bioactive Materials on Pulp-Dentin Complex Regeneration in the Assessment of Cone Bone Computed Tomography (CBCT) and Computed Micro-Tomography (Micro-CT) from a Present and Future Perspective-A Systematic Review.Journal of clinical medicine · 2022Review
- Present status and future directions-Vital pulp treatment and pulp preservation strategies.International endodontic journal · 2022Review
- The Four Pillars for Successful Regenerative Therapy in Endodontics: Stem Cells, Biomaterials, Growth Factors, and Their Synergistic Interactions.Stem cells international · 2022Review
- Effectiveness of Direct Pulp Capping Bioactive Materials in Dentin Regeneration: A Systematic Review.Materials (Basel, Switzerland) · 2021Review
- Effect of Photobiomodulation Therapy following Direct Pulp Capping on Postoperative Sensitivity by Thermal Stimulus: A Retrospective Study.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2021Article
- The Influence of New Silicate Cement Mineral Trioxide Aggregate (MTA Repair HP) on Metalloproteinase MMP-2 and MMP-9 Expression in Cultured THP-1 Macrophages.International journal of molecular sciences · 2020Article
- Bio-Inductive Materials in Direct and Indirect Pulp Capping-A Review Article.Materials (Basel, Switzerland) · 2020Review
- Multidisciplinary Management of a Double Immature Permanent Tooth: A Case Report.Iranian endodontic journal · 2020Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo histologically evaluate the morphology of the newly formed mineralized tissue and of the adjacent cells, in intact human teeth subjected to mechanical pulp exposure and capping with a fast-setting mineral trioxide aggregate (RetroMTA). MATERIALS AND
methodsSeven caries-free third molars from three adults were subjected to pulp exposure, direct capping with RetroMTA, and restoration with a composite resin. Seven months later, the teeth were clinically and radiographically evaluated, extracted, and subjected to histological processing and evaluation.
resultsAll teeth were clinically and radiographically inconspicuous and showed no presence of severe inflammatory reactions. Bacteria were absent in all teeth. All cases exhibited some degree of mineralized tissue in the area of exposure to varying extent. This newly formed mineralized tissue was mostly atubular and did not display the features of regular dentine in any of the cases. No cells exhibiting the features of odontoblasts or odontoblast-like cells were observed. Instead, the cells exhibited a flat or cuboidal shape, resembling fibroblasts.
conclusionsWhen the exposed pulps were directly capped with RetroMTA, the new calcified hard tissue was not "regular dentine," and did not seem to be the product of genuine odontoblast differentiation. These results suggest that the formation of calcified tissues after direct pulp capping with RetroMTA may be more appropriately regarded as a reparative process than as a genuine regeneration response. CLINICAL RELEVANCE: This is the first histological study on humans showing that regular dentine was not regenerated when a bioactive pulp-capping material (RetroMTA) was placed over exposed pulp tissue.
trial registrationNCT03631511.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.